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Organic-inorganic composite flower-like coating and preparation method thereof

An inorganic composite and flower-like technology, applied in coatings, metal material coating processes, prostheses, etc., can solve the problems of simultaneous biocompatibility, difficulty in achieving corrosion degradation, and less zinc, to ensure activity and Stability, beneficial to three-dimensional growth and differentiation, effects of regulated release

Active Publication Date: 2020-07-31
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the surface modification of zinc is still in its infancy.
In the prior art, there are few studies on the surface modification of zinc, which only focus on controlling the corrosion degradation rate of zinc or improving its biocompatibility. It is difficult to achieve both corrosion degradation and biocompatibility at the same time, and few Hybrid Surface Modification Strategies Involving Biological Functions

Method used

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  • Organic-inorganic composite flower-like coating and preparation method thereof
  • Organic-inorganic composite flower-like coating and preparation method thereof
  • Organic-inorganic composite flower-like coating and preparation method thereof

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preparation example Construction

[0033] A method for preparing an organic-inorganic composite flower-like coating provided in an embodiment of the present invention includes:

[0034] S1. Pretreatment of the metal base layer.

[0035] In this embodiment, the metal base layer is zinc base layer. Zinc is a biodegradable biomaterial, and choosing a zinc-based layer to prepare an organic-inorganic composite flower-like coating can obtain good biocompatibility. Furthermore, when the coating is prepared on the surface of the zinc-based layer, the surface of the zinc-based layer can release zinc ions in situ, and the zinc ions released in situ can combine with phosphate in the subsequent solution, making the coating more stable.

[0036] It should be noted that, in other optional embodiments of the present invention, the above-mentioned metal base layer can also choose other degradable metal biomaterials in the field as the base layer.

[0037] Further, the metal base layer is polished to a mirror surface.

[003...

Embodiment 1

[0074] An organic-inorganic composite flower-like coating provided in this embodiment is prepared by the following steps:

[0075] A. Polish the zinc metal to 2000# with water-grinding paper, and then polish it. After polishing, clean it with deionized water and absolute ethanol under ultrasonic conditions for 3 times, each time for 5 minutes, take it out and dry it;

[0076] B. Configuration solution, 10g / L Ca(NO 3 ) 2 4H 2 O,6g / L Zn(NO 3 )·6H 2 O,28g / L NaH 2 PO 4 2H 2 O, adjust the pH to 4.5 with NaOH, add 1 mg / mL phenylalanine, 0.5 mg / mL cysteine, 2 mg / mL bovine serum albumin, 0.5 mg / mL chitosan (dissolved with dilute hydrochloric acid) ),spare;

[0077] C. Submerge the sample obtained in step A in the solution prepared in B, and place it in a water bath at 37.5°C for 3 hours; take it out and dry it, and set it aside for later use.

Embodiment 2

[0079] An organic-inorganic composite flower-like coating provided in this embodiment is prepared by the following steps:

[0080] A. Polish the zinc metal to 2000# with water-grinding paper, and then polish it. After polishing, clean it with deionized water and absolute ethanol under ultrasonic conditions for 3 times, each time for 5 minutes, take it out and dry it;

[0081] B. Configuration solution, 10g / L Ca(NO 3 ) 2 4H 2 O,7g / L Zn(NO 3 )·6H 2 O,28g / L NaH 2 PO 4 2H 2 O, adjust the pH to 4.5 with NaOH, add 1 mg / mL of phenylalanine for subsequent use;

[0082] C. Submerge the sample obtained in step A in the solution prepared in B, and place it in a water bath at 37.5°C for 3 hours; take it out and dry it, and set it aside for later use.

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Abstract

The invention relates to the field of surface modification of biological materials and specifically relates to an organic inorganic compound flower-like coating and a preparation method thereof. The preparation method comprises the following steps: soaking a metal substrate in a mixed solution of zinc phosphate solution and biological active organic molecular solution, and then performing liquid deposition for 2.5-4 hours at 36-38 DEG C. A liquid deposition method is adopted for preparing a compound coating on the metal substrate after the zinc phosphate solution and the biological active organic molecular solution are mixed, and on the basis of a chemical coordination principle, organic molecules and inorganic components are compounded and hybridized so as to form a special flower-like topological structure, so that the activity and stability of organic molecules are guaranteed, and meanwhile, the biological activity and biocompatibility of coating are promoted under the synergistic effect of inorganic components, organic active molecules and special flower-like structure, the deposition of active calcium phosphate can be induced and the growth, proliferation and adhesion of osteoblasts can be boosted. Besides, the corrosion degradation rate of zinc substrate can be effectively restrained and the release of zinc ions can be regulated and controlled.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to an organic-inorganic composite flower-like coating and a preparation method thereof. Background technique [0002] As a new biodegradable metal biomaterial, zinc has received more and more attention. [0003] However, the surface modification of zinc is still in its infancy. In the prior art, there are few studies on the surface modification of zinc, which only focus on controlling the corrosion degradation rate of zinc or improving its biocompatibility. It is difficult to achieve both corrosion degradation and biocompatibility at the same time, and few Involves biofunctional complex hybrid surface modification strategies. Contents of the invention [0004] The first object of the present invention is to provide a method for preparing an organic-inorganic composite flower-like coating. The organic-inorganic composite flower-like coating prepared by the method grows a speci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/32A61L27/34A61L27/28A61L27/54A61L27/50C23C18/12
CPCA61L27/047A61L27/28A61L27/32A61L27/34A61L27/50A61L27/54A61L2420/04A61L2420/06A61L2430/02C23C18/1208C08L89/00C08L5/08
Inventor 万国江钱军余莫小山蒲世民鲜鹏唐帅张文泰黄楠
Owner SOUTHWEST JIAOTONG UNIV
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