Synthetic method of active bagasse xylan o-toluic acid esterification-g-AM

A technology of methyl benzoate and synthesis method, which is applied in the direction of drug combination, antibacterial drugs, antineoplastic drugs, etc., can solve the problems of structural defects and low activity, achieve enhanced biocompatibility, broad application prospects, Improve the effect of biological activities such as antitumor and antibacterial

Inactive Publication Date: 2019-03-01
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Xylan is a biologically active substance in polysaccharides, but

Method used

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  • Synthetic method of active bagasse xylan o-toluic acid esterification-g-AM
  • Synthetic method of active bagasse xylan o-toluic acid esterification-g-AM
  • Synthetic method of active bagasse xylan o-toluic acid esterification-g-AM

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Experimental program
Comparison scheme
Effect test

Embodiment

[0037] (1) Dry 10 g of bagasse xylan in a constant-temperature vacuum oven at 60° C. for 24 hours to constant weight to obtain dry-based bagasse xylan.

[0038] (2) Weigh 4 g of bagasse xylan obtained in step (1) and add it into a 250 mL four-necked flask, then add 20 mL of deionized water, and fully stir at 30° C. for 25 minutes.

[0039] (3) Weigh 0.6g of ammonium persulfate and 0.48g of sodium bisulfite in a 50mL beaker in sequence, then add 20-30mL of deionized water, stir evenly to obtain an initiator solution, and set aside.

[0040] (4) Weigh 4g of AM into a 50mL beaker, then add 30mL of deionized water into the beaker, stir evenly to obtain a monomer solution, pour it into a 100mL constant pressure dropping funnel, and set aside.

[0041] (5) Add dropwise the monomer solution obtained in step (4) to the reaction system in step (2), control the temperature at 50° C., and complete the dropwise addition in 6 hours. When adding to 1 / 2 of the monomer solution volume, add 0...

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Abstract

The invention discloses a synthetic method of active bagasse xylan o-toluic acid esterification-g-AM. The synthetic method adopts natural macromolecular biological active bagasse xylan as a main raw material, adopts ammonium persulfate and sodium hydrogen sulfite as an initiation system, adopts N,N'-methylene bisacrylamide as a cross-linking agent to prepare bagasse xylan-g-AM; and then the synthetic method adopts the bagasse xylan-g-AM as a raw material, adopts o-toluic acid as an esterification agent, and adopts toluenesulfonic acid as a catalyst to prepare the bagasse xylan o-toluic acid esterification-g-AM in the N,N-dimethylacetamide (DMA) solvent. A product prepared in the synthetic method of the invention performs the esterification reaction on the basis of grafting, and a final synthesized product of bagasse xylan o-toluic acid esterification-g-AM not only solves the problem that the bagasse xylan is poor in solubility and enlarges the application range, but also further improves the biological activity of the bagasse xylan by introducing the active groups of acrylamide (AM) and o-toluic acid.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for synthesizing anticancer bioactive bagasse xylan o-tolylated-g-AM. Background technique [0002] Plant polysaccharides have gradually attracted the attention of researchers at home and abroad due to their various biological functions such as inhibiting the proliferation of tumor cells, slowing down the oxidation of substances, and improving the immunity of organisms. Xylan is a biologically active substance in polysaccharides, but due to the structural defects of xylan itself, its activity is low. Chemical modifications such as esterification and graft copolymerization of xylan can effectively change its molecular space structure and improve its anti-biological activity. What is even more exciting is that xylan can greatly improve its anticancer activity after molecular design and chemical modification such as esterification and grafting. [0003] Studies ...

Claims

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Application Information

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IPC IPC(8): C08B37/14C08F251/00C08F220/56C08F222/38C08F8/14A61P35/00A61P31/04
CPCA61P31/04A61P35/00C08B37/0057C08F8/14C08F251/00C08F220/56C08F222/385
Inventor 李和平柴建啟耿恺张淑芬武晋雄张俊龚俊
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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