58 results about "Methylbenzoprim" patented technology

The invention discloses a coproduction method of methylbenzoic acid, methyl benzoate and benzenedicarboxylic acid diester. The method comprises the following steps: (1) continuously introducing xylene, a catalyst and oxygen-containing gas into an oxidation reactor for a reaction, and controlling oxygenic concentration in the tail gas to not exceed 5% by controlling introduction amount of the oxygen-containing gas to obtain an oxidation reaction liquid; (2) feeding the obtained oxidation reaction liquid into a predistillation tower for distillation separation to obtain a low-boiling-point component and a predistillation tower bottom liquid; (3) feeding the predistillation tower bottom liquid into a distillation tower for distillation to obtain a methylbenzoic acid product and a distillationtower bottom liquid; (4) mixing the distillation tower bottom liquid and alcohol for an esterification reaction, and controlling the reaction endpoint to be lower than 0.5wt% of the content of methylbenzoic acid to obtain an esterification reaction liquid; (5) performing distillation separation on the obtained esterification reaction liquid to obtain methyl benzoate and benzenedicarboxylic acid diester products. The method has the advantages that the process is simple, equipment investment is low, and the method is environmentally friendly and has good comprehensive economic benefits.

The invention discloses an abrasion-resistant aluminum alloy doorframe. The abrasion-resistant aluminum alloy doorframe comprises an aluminum alloy body and an abrasion-resistant coating which is coated on the surface of the aluminum alloy body, wherein the aluminum alloy is formed by fusing aluminum and chromium at high temperature; the abrasion-resistant coating comprises cis-polybutadiene, a filling agent, a plasticizing agent and a coupling agent; the filling agent is aluminum oxide powder; the plasticizing agent is diethylene glycol binary m-methyl benzoate; the coupling agent is isopropyl titanate tristearate; the percentages by weight of components in the abrasion-resistant coating are as follows: the cis-polybutadiene accounts for 57-77%; the aluminum oxide powder accounts for 17-24%; the diethylene glycol binary m-methyl benzoate accounts for 4-11%; the isopropyl titanate tristearate accounts for 2-8%. The aluminum alloy itself is high in mechanical strength; the surface of the aluminum alloy is protected by the abrasion-resistant coating; the aluminum alloy has the characteristics of sagging resistance, abrasion resistance, impossibility in damage, long service life and good using effect.

The invention relates to a method for preparing a sofosbuvir intermediate [(2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl] methylbenzoate represented by formula (II) and recovering a byproduct (2R,3R,4S)-4-fluoro-2,5-dihydroxy-4-methylpentane-1,3-diyl]dibenzoate represented by formula (III). The method comprises the following steps: (1) reacting a compound (I) 3,5-dibenzoyl-2-deoxy-2-fluoro-2-methyl-D-ribosinic acid-gamma-lactone in a first solvent under the action of a reducing agent at a temperature of from 0 DEG C to the reflux temperature of the first solvent for 1-20 hours to produce the sofosbuvir intermediate (II) and the byproduct (III); and (2) filtering the above product to obtain a filter cake which is the byproduct (III), dissolving the filter cake in a second solvent, and reacting the obtained solution in an acidic environment with the pH value of 1-6 under the action of an oxidant and a catalyst at a temperature from 0 DEG C to the reflux temperature of the second solvent for 0.5-5 hours in order to generate the compound (I).

The invention provides a method for synthesizing 3-alkoxy-4-alkoxycarbonyl phenylacetate and 3-alkoxy-4-alkoxycarbonyl phenylacetic acid. The method for synthesizing 3-alkoxy-4-alkoxycarbonyl phenylacetate comprises: 3-alkoxy-4-methyl benzoate reacts with the chloro-carbonate on the effect of strong base in the organic solution at 190 deg.-0 deg. to obtain the product; the method of the 3-alkoxy-4-alkoxycarbonyl acetic ether cheesed hydrolysis to obtain the 3-alkoxy-4-alkoxycarbonyl phenylacetic acid.

The invention discloses a synthesis method of bagasse xylan o-methylbenzoate-g-AM (Acrylamide) / MMA (Methyl Methacrylate). The synthesis method takes natural macromolecular bioactive bagasse xylan as amain raw material, acrylamide (AM) and methyl methacrylate (MMA) as a mixed grafting monomer, and ammonium persulfate and sodium hydrogensulfite as an initiation system to synthesize bagasse xylan-g-AM / MMA; then 4-dimethylaminopyridine is used as a catalyst and o-methylbenzoic acid is used as an esterification agent; the catalyst and, esterification agent and a grafting copolymer bagasse xylan-g-AM / MMA are subjected to catalystic esterification reaction in an N,N-dimethylacetylamide (DMA) solvent to synthesize a final product bagasse xylan syringateo-methylbenzoate-g-AM / MMA. According to thesynthesis method disclosed by the invention, three types of anti-bioactivity groups are introduced through esterification, grafting and crosslinking compound modification of the bagasse xylan, so thatthe activity including water solubility, cancer resistance and, bacterium resistance and the like of original bagasse xylan is enhanced; the bagasse xylan o-methylbenzoate-g-AM / MMA has relatively high application value in the fields including medicines and, foods and the like.

The invention relates to a synthesis method of a key sofosbuvir intermediate shown as a formula (I). The synthesis method comprises the following steps: with a compound 3,5-dibenzoyl-2-deoxy-2-fluoro-2methyl-D-ribose-gamma-lactone as a raw material, selectively reducing by using modified passivated red aluminum to produce a compound [(2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl] methyl benzoate, chlorinating the compound [(2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl] methyl benzoate, performing condensation on the compound [(2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl] methyl benzoate and N-benzoyl-O-(trimethylsilyl)cytosine to produce the sofosbuvir intermediate (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine-3',5'-dibenzoate. By the synthesis method, the compound [(2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl] methyl benzoate is highly selectively prepared by replacing commonly used trifluoroethanol with a passivating agent morpholine; in the reaction process, byproducts are reduced, so that progression of a subsequent reaction is facilitated; and the synthesismethod has a huge industrial production prospect.

The invention discloses a method for preparing phthalic acid through liquid phase catalytic oxidation of xylene, wherein the method is suitable for liquid phase oxidation reactions of p-xylene, o-xylene and m-xylene. Specifically the method comprises that phthalic acid ester or methyl benzoate is adopted as a solvent, air or oxygen is adopted as an oxidant, oil-soluble Co or Mn is adopted as a catalyst, 2,2-bipyridine and other complexing agents are adopted as additives, and oxidation is performed to obtain the phthalic acid, wherein the reaction temperature is 150-240 DEG C, and the reaction pressure is 0.5-2.0 Mpa. According to the present invention, the technology has the good universality and is suitable for the oxidation of p-xylene, o-xylene and m-xylene, the consumption of the catalyst in the method is less, the catalyst is not easily subjected to complexation inactivation, the concentration fluctuation range of the catalyst during the reaction process is small, the running period is long, the reaction effect is good, the flexible adjusting according to different reaction characteristics can be achieved, and other advantages are provided.

The invention provides an aluminum alloy door frame. The aluminum alloy door frame comprises an aluminum alloy base material and a functional coating with which the surface of the aluminum alloy base material is coated. The aluminum alloy base material is prepared from, by weight, 5-8 parts of silicon, 6-10 parts of nickel, 5-8 parts of chromium, 1-2 parts of copper, 0.5-1 part of iron, 1-2 parts of manganese, 1-2 parts of magnesium, 1-2 parts of zinc, 0.5-1 part of titanium, smaller than or equal to 200 ppm of calcium, 0-0.2 part of lead, 0-0.05 part of cadmium and the balance aluminum. The functional coating is prepared from 20-50 parts of butadiene rubber, 20-50 parts of filler, 8-10 parts of plasticize and 3-10 parts of coupling agent. The filler is prepared from, by mass, 30-60% of aluminum oxide-titanium dioxide composite, 20-40% of manganese dioxide and 10-40% of silicon dioxide. The lubricating agent is organic silicon oil, the coupling agent is isopropyl trioleate trioleate, and the plasticizer is diethylene glycol dimethyl benzoate. The aluminum alloy door frame is high in surface strength, good in corrosion resistance and scraping resistance and attractive in appearance.

The invention discloses a method for detecting atomoxetine hydrochloride enantiomer by reversed-phase liquid chromatography, which belongs to the field of pharmaceutical analysis, and adopts a polysaccharide derivative reversed-phase coating type chiral chromatographic column of which the surface of silica gel is coated with cellulose-tri (4-methyl benzoate) as a filler; and a mixed solution of a potassium hexafluorophosphate solution and acetonitrile is used as a mobile phase, the column temperature is 25-35 DEG C, the flow velocity is 0.5-0.8 ml / min, an ultraviolet detector is adopted, and the wavelength is 200-250 nm. According to the present invention, the atomoxetine hydrochloride and the enantiomer can be directly and effectively separated, the accuracy of the detection result is good, the sensitivity is high, and compared with the existing normal phase chromatography or precolumn derivatization reverse chromatography, the operation is simple, the cost is low, and the analysis time is short, such that the good guarantee is provided for the quality control of the atomoxetine hydrochloride and the preparation thereof.

The invention discloses a method for co-producing methyl benzoic acid, methyl benzoate and phthalic acid diester, comprising: (1) continuously feeding xylene, a catalyst and an oxygen-containing gas into an oxidation reactor to carry out reaction, by controlling the amount of oxygen-containing gas to control the tail oxygen concentration to be no more than 5%, to obtain an oxidation reaction liquid; (2) enter the obtained oxidation reaction liquid into an initial distillation tower for rectification separation, to obtain low boiling point components and initial (3) enter the rectifying tower still liquid into the rectifying tower for rectification to obtain toluic acid product and rectifying tower still liquid; (4) mix the rectifying tower tower liquid with alcohol , carry out the esterification reaction, control the reaction end point to be that the content of toluic acid<0.5wt%, obtain the esterification reaction solution; (5) carry out rectification separation with the esterification reaction solution obtained, obtain methyl benzoic acid ester respectively and diester phthalate products. The invention has the advantages of simple process, less equipment investment, environmental protection and good comprehensive economic benefits.

The invention discloses an HPLC (High Performance Liquid Chromatography) method for measuring content of D-4-methylsulfonylphenyl serine ethyl ester, comprising the following steps of: preparing a solution from D-4-methylsulfonylphenyl serine ethyl ester with a mixed solvent of normal propyl alcohol and carbinol; filtering with a microporous membrane; coating the chiral column of the stationary phase of cellulose-tris (4-methyl benzoate) on the surface of silica gel; detecting in the presence of proper detection wavelength, flow rate and column temperature by taking a mixed solution of normal hexane, an organic modifier and organic base; and then calculating the content of a sample according to a spectrogram. The D-4-methylsulfonylphenyl serine ethyl ester and L-4-methylsulfonylphenyl serine ethyl ester can be effectively separated, and the content of the D-4-methylsulfonylphenyl serine ethyl ester can be accurately measured by adopting the method. The method is simple and convenient, reliable and rapid and has high sensitivity and good repeatability and specificity and lays foundation for the formulation of the quality standard of the D-4-methylsulfonylphenyl serine ethyl ester.

The invention relates to the technical field of biopharmacy, in particular to preparation of a sofosbuvir intermediate, and more particularly relates to a preparation method of the sofosbuvir intermediate ((2R, 3R, 4R)-3-benzoyloxy-4-fluoro-5-chloro-4-methyltetrahydrofuran-2-yl) methyl benzoate; and a compound shown in a formula a reacts with modified red aluminum to prepare a compound shown in a formula b, then the compound shown in the formula b is subjected to a chlorination reaction in an oxalyl chloride / chlorobenzene solution to prepare a compound shown in a formula c, and finally the compound shown in the formula c reacts with a compound with a structure shown in a formula e to prepare a target compound shown in a formula d. The preparation process is simple in reaction condition, easy to operate and low in cost; the hydrolysis operation is reduced in the post-treatment process of the chlorination stage, so that the wastewater amount is reduced, and the method is more environment-friendly; and the preparation process disclosed by the invention is high in yield, high in product purity, more stable in product and suitable for large-scale production.

The present invention provides for a composition of matter comprising: poly(9,9-dioctylfluorene-co-fluorenone-co-methylbenzoic ester)(PFM), carbon nanotubes (CNT), and sulfur particles nanocomposite, wherein the nanocomposite is porous. The present invention also provides for an electrode comprising: poly(9,9-dioctylfluorene-co-fluorenone-co-methylbenzoic ester)(PFM), carbon nanotubes (CNT), and sulfur particles nanocomposite, wherein the nanocomposite is porous. The present invention also provides for a lithium sulfur (Li—S) battery comprising: an electrode comprising poly(9,9-dioctylfluorene-co-fluorenone-co-methylbenzoic ester)(PFM), carbon nanotubes (CNT), and sulfur particles nanocomposite, wherein the nanocomposite is porous.

The invention discloses a method for preparing donepezil by virtue of simulated moving bed chromatographic separation. A laevo isomer and a dextro isomer are separated out from the donepezil by adopting a chiral column Chiralcel-OJ and taking silica gel coated with cellulose-tri(4-methyl benzoate) as a stationary phase and absolute ethyl alcohol as a moving phase. Due to the continuity of the simulated moving bed chromatographic separation, the production efficiency can be greatly improved and the production cost can be reduced; the whole separation process does not involve with any toxic solvent.

The invention provides a preparation method of telbivudine, wherein the method comprises the following steps: 1) adding thymine and hexamethyl disilylamine to an organic solvent, and carrying out a reaction, wherein the organic solvent comprises one of dimethyl sulfoxide, N,N-dimethylformamide, and N,N-diethyl formamide; 2) adding (2S,3R)-5-chloro-2-(((4-methyl benzoyl)oxo)methyl)tetrahydrofuran)-3-yl)-4-methyl benzoate, carrying out a reaction, adding an NaHCO3 solution, stirring and filtering, and carrying out reduced pressure concentration on the filtrate; and 3) adding an alcohol solvent, then adding sodium ethoxide, carrying out a reaction, adding cation exchange resin, and carrying out heat preservation stirring; and cooling and filtering, concentrating the filtrate until a solid is precipitated, and crystallizing, to obtain a telbivudine crude product. The adopted reagents and raw materials both have low toxicity; the method has the advantages of simple preparation process, mild reaction conditions, easy operation, stable physical and chemical properties of the raw materials, fewer by-products and high yield.