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Microelectronic sensors for non-invasive monitoring of physiological parameters

A physiological parameter, non-invasive technology, applied in the direction of micro sensor, sensor, humidity sensor, etc., can solve the problem of sacrificing the switch-on performance of the device

Inactive Publication Date: 2021-10-22
EPITRONIC HLDG PTE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many publications employ various approaches to achieve a normally closed device with minimal impact on drain current, they unfortunately sacrifice the turn-on performance of the device

Method used

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  • Microelectronic sensors for non-invasive monitoring of physiological parameters
  • Microelectronic sensors for non-invasive monitoring of physiological parameters
  • Microelectronic sensors for non-invasive monitoring of physiological parameters

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0273] Example 1: Charge Sources for Single Point PC-HEMT Signals

[0274] At the onset of the pulse arrival time (PAT) cycle in the chest, there are different ways to detect the primary cardiac activity signal that can be used for blood pressure calculations. The inventors of the present invention demonstrated that, in some embodiments, single point PC-HEMT signals actually arise from cardiac electric dipole field changes rather than mechanical changes in the heart / body.

[0275] In applied biomedical research, heart vibrations are measured by techniques known as ballistocardiography (BCG of whole body movements) or vibrocardiography (SCG of mainly thoracic movements). The mechanical BCG signal follows the electrical signal, with a delay of approximately 30-40 ms. In BCG, the mechanical motion of the heart is detected by measuring force or acceleration from the chest. Alternatively, using remote BCG recordings, the pumping activity of the heart can be monitored. It is usua...

example 2

[0279] Example 2: Cardiovascular and Lung Monitoring Using PC-HEMT Sensors

[0280] Referring now to Figure 22, which shows a heartbeat waveform (Wiggers diagram, cited from WikiCommons 2008) recorded using different conventional instruments. Figure 23 A heartbeat detected at the wrist with a single point PC-HEMT sensor and a pulse oximeter is shown compared to a standard signal. The oximeter signal follows the aortic pressure waveform with a time delay ΔΤ that is common with the device installed. Figure 24a Central venous pressure (CVP) data synchronized with ECG and cardiac signal data recorded with a PC-HEMT sensor are shown. Figure 24bThe first derivative of the ECG recording curve obtained from 100 combined measurements using the PC-HEMT sensor is shown. It is consistent with CVP readings, enabling non-invasive CVP to be performed using one embodiment of the sensor of the present application in conjunction with the ECG described above. Therefore, cardiac signals rec...

example 3

[0283] Example 3: Flow test

[0284] A prototype single-point measurement PC-HEMT sensor was used to perform a full cardiac cycle activity recording, including the physical motion of the left and right atria, in a real-time synchronized manner with the cardiac polarization / depolarization electrocardiographic dynamics. The technique described in this application allows non-invasive cardiac diagnostics to be performed, which can alternatively be performed only by invasive left and right atrial cardiac catheterization with simultaneously recorded ECG. Furthermore, the PC-HEMT sensor of some embodiments of the present application enables access to a single site on the patient's body where cardiac measurements need to be taken. This allows for the smooth integration of PC-HEMT sensors into wristwatch form, revolutionizing the entire approach to cardiovascular and pulmonary diagnostics and therapy monitoring. Furthermore, with the integrated PC-HEMT sensor, cardiac telemedicine in ...

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Abstract

The present invention discloses that in some embodiments PC-HEMT based microelectronic sensors are used in cardiovascular and pulmonary monitoring, electrocardiogram signal detection and measurement, primary cardiac activity signal detection and central venous pressure and heart rate variability measurement, left and right Atrial pressure measurement, phonocardiogram recording, S2 split phenomenon detection, respiratory dynamic measurement and lung activity diagnosis, brain activity monitoring and measurement and monitoring of electrical signals related to EEG, and ocular pressure diagnosis.

Description

technical field [0001] The present application relates to the field of microelectronic sensors based on high electron mobility transistors and their use in the detection and continuous monitoring of electrical signals generated by the human body. In particular, the present application relates to open-gate pseudo-conducting high electron mobility transistors and their use in non-invasive monitoring of human physiological parameters. Background technique [0002] The state of human health is determined by many self-interdependent physiological parameters. Not all of these parameters are equally informative and important. Furthermore, not all of these parameters can be easily and precisely monitored since their measurement requires special conditions, expensive medical equipment and materials. When designing an integrated monitoring system, not only the importance of the measured parameter must be assessed, but also its measurement technique and potential for application to r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00H01L29/778
CPCA61B7/00A61B2562/0204A61B2562/0209A61B2562/0247A61B2562/0261A61B2562/028A61B2562/029A61B2562/043A61B2562/12A61B2562/164A61B5/00A61B5/25G01N27/414A61B1/2736A61B3/16A61B5/0006A61B5/021A61B5/08A61B5/1102A61B7/045A61B5/291A61B5/316A61B5/349H01L29/2003H01L29/205H01L29/7786
Inventor 阿亚尔·拉姆阿米尔·利希滕斯坦
Owner EPITRONIC HLDG PTE LTD
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