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A gastrointestinal contrast agent for x-ray examination

A gastrointestinal radiography and X-ray technology, which is applied in the preparation of X-ray contrast agents, preparations for in vivo tests, pharmaceutical formulations, etc., can solve the problems of aggravated colon inflammation, long waiting time, intestinal irritation, etc., and achieve high intestinal Road propulsion rate, improvement effect, effect of preventing diarrhea

Inactive Publication Date: 2021-07-23
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the ileocecal area of ​​the lower gastrointestinal tract, conventional contrast agents are used, and there are problems such as poor contrast effect and long waiting time after taking contrast agents. exercise, but mannitol itself is a drug with high osmotic pressure, which will cause certain irritation to the intestinal tract in the intestinal tract, especially when the patient suffers from colitis and other diseases, it will aggravate the inflammation of the colon and cause diarrhea

Method used

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  • A gastrointestinal contrast agent for x-ray examination
  • A gastrointestinal contrast agent for x-ray examination
  • A gastrointestinal contrast agent for x-ray examination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] Preparation

[0010] Dissolve curcumin in acetic acid, then add the prescribed amount of mannitol, then add the prescribed amount of water and barium sulfate, and stir evenly.

[0011] Embodiment and comparative example formula are as follows table (unit: weight part)

[0012]

[0013] Pharmacological Example

[0014] Healthy SD mice (about 10 months old), weighing 180-220 g. Both sexes were raised in an air-conditioned room, fed standard pellet feed, and had free access to water and food.

[0015] modeling

[0016] The rats were fasted for 24 hours, lightly anesthetized with ether, inserted a silicone tube with an outer diameter of 2mm into the anus of the rat about 8cm, injected 2ml of 10% acetic acid solution into the tube, and injected 5ml of normal saline after 10-20s to eliminate The effect of acetic acid, after naturally waking up, put it back into the cage for normal feeding, complete the modeling, and divide the rats that the modeling has completed into ...

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Abstract

A gastrointestinal contrast agent for X-ray examination, characterized in that the contrast agent consists of 300-400 parts by weight of barium sulfate, 10-20 parts by weight of mannitol, 0.3-0.5 parts by weight of curcumin, 2- It consists of 3 parts by weight of acetic acid and 0-300 parts by weight of water.

Description

technical field [0001] The invention relates to a contrast agent for X-ray inspection. Background technique [0002] During X-ray contrast examination of the digestive tract, since the density of the abdominal organs and tissues is roughly similar, it is necessary to introduce a contrast agent that is harmless to the human body, such as barium and other elements with a large atomic coefficient. X-rays can pass through human tissue and reach the film to form fog, and artificially increase the display contrast to achieve the ideal inspection effect. Therefore, barium sulfate and the like are often used as contrast agents. However, due to the complexity of the human digestive tract, oral administration of barium sulfate (barium meal) as a contrast agent has a better contrast effect on the upper digestive tract. For the colorectum in the lower gastrointestinal tract, a contrast medium enema can be used. However, the use of conventional contrast agents in the ileocecal area of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04
CPCA61K49/0404
Inventor 余美红李恺璇周鹤俊孔令芹
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV