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Eliminating source lamp intensity drift effect using reference measurement between cuvettes

A technology of reference measurement and cuvette, applied in the direction of color/spectral characteristic measurement, measuring device, instrument, etc.

Active Publication Date: 2019-03-15
SIEMENS HEALTHCARE DIAGNOSTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, obtaining such periodic measurements in conventional analyzer systems without affecting system performance due to positioning / alignment issues is challenging

Method used

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  • Eliminating source lamp intensity drift effect using reference measurement between cuvettes
  • Eliminating source lamp intensity drift effect using reference measurement between cuvettes
  • Eliminating source lamp intensity drift effect using reference measurement between cuvettes

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Embodiment Construction

[0034] The following disclosure describes the present invention, according to several embodiments, directed to methods, systems and apparatus involving the use of reference measurements between cuvettes in an in vitro diagnostic system to eliminate the effects of source lamp intensity drift. The technique described here overcomes the cuvette alignment problem of traditional in vitro diagnostic systems using cuvette mapping during start-up. More specifically, cuvette maps are used to identify specific inter-cuvette regions for reference measurements. These reference measurements are further analyzed to verify the validity of the readings and to identify cuvette bath clarity or contamination.

[0035] The tendency of the edges (leading and trailing edges) of the reaction ring vessel to block the light source is used to detect the vessel edge. Using the cuvette mapping technique described here, the photometer collects and analyzes the stream of reads while the reaction ring unde...

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Abstract

A computer-implemented method for calibrating a photometer in an in-vitro diagnostics analyzer includes generating a cuvette map of a reaction ring identifying a plurality of cuvette locations. The cuvette map is used to identify a plurality of reference measurement areas between the plurality of cuvette locations. A plurality of reference measurements are acquired in the reference measurement areas using the photometer. The photometer is automatically calibrated based on a comparison of the reference measurements to a predetermined standard setup of the photometer.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application Serial No. 62 / 365,294, filed July 21, 2016, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention generally relates to methods, systems and devices for obtaining reference measurements between cuvettes in an in vitro diagnostic system. The techniques described herein can be applied, for example, to eliminate the effects of source lamp intensity drift that might otherwise adversely affect the acquisition of photometric measurements. Background technique [0004] In vitro diagnostics (IVD) allow laboratories to aid in the diagnosis of disease based on assays performed on patient fluid samples. IVD includes various types of analytical tests and assays related to patient diagnosis and treatment, which may be performed by analyzing fluid samples taken from the patient's bodily fluids or abscesses....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/27G01N35/00
CPCG01N35/00693G01N21/274G01N2201/0256G01N2201/0415G01N21/253G01N2201/12715G01N35/00732
Inventor J.K.约瑟夫B.阿布拉罕F.克鲁夫卡T.贝
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC
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