Application of nifedipine in medium and severe hypertension treating drugs

Abstract

The invention provides an application of nifedipine in medium and severe hypertension treating drugs and belongs to the technical field of medical drugs. The application is specifically an applicationof sub-lingual administration of 5 mg nifedipine in medium and severe hypertension first aid drugs. The frequency of the oral mucosa administration is as follows: sub-lingual administration initially; or, after sub-lingual administration initially, carrying out sub-lingual administration once every 20 minutes, no more than three times of sub-lingual administration repeatedly are available, that is, the total administration number of times does not exceed 4 times. The preparation from, the administration dosage, the administration path and the administration scheme are provided, and the safetyand effectiveness of sub-lingual administration of small dosage 5 mg nifedipine applied in medium and severe hypertension first aid drugs. The application is a novel breakthrough of the pharmacy modeof nifedipine. The nifedipine dropping pills as preparation transform are primarily used for treating stenocardia and hypertension. The nifedipine dropping pills are quick to take effect by sub-lingual administration, can be stopped anytime, are easily accepted and are also suitable for patients hard to swallow.

Description

technical field [0001] The invention relates to the technical field of medical medicines, in particular to the application of nifedipine in medicines for treating moderate and severe hypertension. Background technique [0002] Hypertension is a common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. Stroke, myocardial infarction, heart failure and chronic kidney disease may all become its main complications. From 115 / 75mmHg to 185 / 115mmHg, every 20mmHg increase in SBP or 10mmHg increase in DBP will double the risk of cardiovascular and cerebrovascular complications. [0003] 30% of the world's people die from cardiovascular diseases such as stroke and heart accident, of which 62% of stroke deaths are directly caused by high blood pressure, and 49% of myocardial infarctions are directly caused by high blood pressure. Reducing the blood pressure level of hypertensive patients is the key to reducing cardiovascular and cerebrov...

AI Technical Summary

Problems solved by technology

Sublingual administration of nifedipine in the treatment of hypertension is difficult to grasp in terms of speed, magnitude and duration of blood pressure reduction, which may have adverse effects on patients and even lead to serious consequences

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