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Application of eight-medicine composition Chinese Eaglewood dropping pill in preparation of medicine for treating Alzheimer's disease

A technology of Alzheimer's disease and agarwood pills, applied in the field of biomedicine, can solve the problems of many onset links, no specific drugs, and high price.

Inactive Publication Date: 2019-04-02
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The etiology of AD is complex, the course of the disease is long, and there are many stages of pathogenesis, which requires long-term medication. At present, the main anti-Alzheimer's disease drugs are acetylcholinesterase inhibitors (such as galantamine) and N-methyl-D-aspartate Acid receptor (NMDA receptor) antagonists (such as memantine), but the above drugs are expensive and have significant side effects such as hallucinations, confusion, dizziness, headache, and fatigue after taking the drugs, and can only control but not reverse the patient's condition
[0006] So far, there is no specific drug for the treatment of AD, and most drugs are still in the stage of basic research and clinical trials

Method used

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  • Application of eight-medicine composition Chinese Eaglewood dropping pill in preparation of medicine for treating Alzheimer's disease
  • Application of eight-medicine composition Chinese Eaglewood dropping pill in preparation of medicine for treating Alzheimer's disease
  • Application of eight-medicine composition Chinese Eaglewood dropping pill in preparation of medicine for treating Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 The water decoction of Bawei Chenxiang Wan significantly delays the muscle paralysis of AD Caenorhabditis elegans

[0025] 1. Biomaterials

[0026] (1) Caenorhabditis elegans CL4176 was purchased from Caenorhabditis Genetics Center (CGC); it is a transgenic strain that specifically expresses human Aβ in muscle under induction at 25°C 1-42 , Aβ 1-42 Aggregation in muscle tissue eventually leads to nematode paralysis. In this example, the Caenorhabditis elegans CL4176 strain is used as a pathological model for screening anti-AD drugs.

[0027] (2) Escherichia coli OP50 (uracil-leakage mutant), purchased from Caenorhabditis Genetics Center (CGC), used as food for Caenorhabditis elegans.

[0028] 2. Reagents

[0029] (1) Bawei Chenxiang Pills are produced in Tibet Autonomous Region Tibetan Medicine Factory, production batch number 13016A

[0030] (2) Solid NGM (Nematode Growth Medium) medium composition and production (take 1 liter as an example):

[0031] ...

Embodiment 2

[0058] Example 2 Comparison of the effects of frankincense decoction and Bawei Chenxiang Wan decoction in delaying the muscle paralysis of Caenorhabditis elegans in AD

[0059] 1. Preparation of frankincense decoction:

[0060] Take the traditional Chinese medicine frankincense, grind it with a mortar, weigh 0.67g, add 100mL of water, soak for 30min, heat to boil and keep for 30min, naturally cool to room temperature and then centrifuge (12000rpm, 10min), separate the supernatant, precipitate and then use 80mL to remove Soak in ionized water for 10 minutes, then heat to boiling with high heat, then heat for 25 minutes, naturally cool to room temperature and centrifuge (12000rpm, 10min), take the supernatant, combine the two supernatants, and dilute to 50mL to obtain 13.33mg / mL frankincense decoction (based on the amount of crude drug, the same amount of frankincense contained in the 200mg / mL Bawei agarwood decoction).

[0061] 2. Preparation of NGM containing drug decoction ...

Embodiment 3

[0072] Example 3 Comparison of decoction of agarwood and woody composition with decoction of Bawei agarwood pill in delaying AD Caenorhabditis elegans muscle paralysis

[0073] 1. Preparation of water decoction of agarwood and woody composition:

[0074]Take the traditional Chinese medicine agarwood and woody powder, crush them with a powder machine, weigh 1.33g of agarwood and 2.33g of woody, mix well, add 100mL of water, soak for 30 minutes, heat to boil and keep for 30min, naturally cool to room temperature and then centrifuge (12000rpm, 10min), separate the supernatant, precipitate and soak in 80mL deionized water for 10min, then heat to boiling with high heat, then heat for 25min, cool to room temperature naturally and centrifuge (12000 rpm, 10min), take the supernatant, and combine the two Second supernatant, be settled to 50mL, promptly obtain the decoction of 73.33mg / mL agarwood and woody composition (according to crude drug amount, with the decoction of agarwood and w...

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Abstract

The invention belongs to a novel purpose of eight-medicine composition Chinese Eaglewood dropping pill, and more specifically relates to an application of the eight-medicine composition Chinese Eaglewood dropping pill in preparing a medicine for treating Alzheimer's disease. In the present invention, the eight-medicine composition Chinese Eaglewood dropping pill is used as a pathological model ofcaenorhabditis elegans Alzheimer's disease, and the results show that the eight-medicine composition Chinese Eaglewood dropping pill significantly delays the muscular paralysis phenotype of caenorhabditis elegans suffering from Alzheimer's disease, has the significant therapeutic effect on caenorhabditis elegans suffering from Alzheimer's disease, has the potential to treat Alzheimer's disease, and can be used for preparing the medicine for treating Alzheimer's disease.

Description

technical field [0001] The invention relates to a new application of Bawei Chenxiang Pills, in particular to the application of Bawei Chenxiang Pills in the preparation of medicines for treating Alzheimer's disease, and belongs to the field of biomedicine. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is dementia caused by chronic degenerative central nervous system degenerative disease, is the most common cause of dementia and the most common senile dementia. AD is characterized by neuropsychiatric symptoms such as progressive memory impairment, cognitive impairment, personality changes, and language impairment. [0003] Alzheimer's disease is the most common and important brain degenerative disease. With the aging of the global population, the incidence of AD shows a significant upward trend year by year. Most data show that the prevalence rate is about 5% over the age of 65, 20% over the age of 85, and the prevalence rate of women is about 3...

Claims

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Application Information

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IPC IPC(8): A61K36/835A61K9/20A61P25/28A61K33/06
CPCA61K9/20A61K33/06A61K36/185A61K36/22A61K36/285A61K36/324A61K36/835A61K2300/00
Inventor 李红玉段紫云支德娟李洋蒋云龙赵陇和
Owner LANZHOU UNIVERSITY
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