Diagnostic marker for colorectal cancer and detection product for colorectal cancer and application thereof

A diagnostic marker, colorectal cancer technology, applied in the field of medicine, can solve the problem of inconvenient detection of disease progress for patients, and achieve high sensitivity and strong specificity

Active Publication Date: 2019-04-02
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Ulcerative colitis and inflammatory bowel polyps are often regarded as one of the high-risk factors for colorectal cancer. Colonoscopy detection and re-examination are invasive examinations, and it is very inconvenient for patients to detect disease progression

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  • Diagnostic marker for colorectal cancer and detection product for colorectal cancer and application thereof

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Embodiment

[0031] Peripheral blood serum sample collection method: collect 10mL peripheral blood venous sample in the morning on an empty stomach, let it stand at room temperature for two hours, centrifuge at 1000g at 4°C for 15min, separate the upper layer of plasma, and store it at -80°C for later use.

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Abstract

The invention relates to a diagnostic marker for the colorectal cancer and a detection product for the colorectal cancer and an application thereof. The colorectal cancer diagnostic marker comprises aplurality of kinds of secreted protein including one or more of S100A9 protein, tenascin-c protein and CEA protein. The diagnostic marker has characteristics of high sensitivity and strong specificity. The area under the roc curve of the diagnostic model is 0.902. The confidence level of the diagnosis result is much higher than that of the diagnosis result using a single protein marker. The diagnostic marker has the important significance in colorectal cancer diagnosis and treatment. Besides, the detection product of the colorectal cancer includes the colorectal cancer diagnostic marker. In addition, the invention also puts forward application of the colorectal cancer diagnostic marker in preparation of a product for the auxiliary diagnosis of the colorectal cancer.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a colorectal cancer diagnostic marker, a colorectal cancer detection product and an application thereof. Background technique [0002] Colorectal cancer is one of the most common malignant tumors of the digestive tract in the world. In the past 20 years, the incidence and mortality of colon cancer have been on the rise in most countries in the world. Most colon cancer patients are found to be in the late stage, and the prognosis poor. The current screening and diagnosis methods for colon cancer are invasive, and colonoscopy is still the gold standard for its screening and diagnosis. In recent years, fecal occult blood test is the most commonly used non-invasive test method in colorectal cancer screening, but its sensitivity and specificity are low. If simple serum detection can be applied to its early diagnosis, it will contribute to the prevention and prognosis of colon cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/574G01N33/57419G01N33/57446G01N33/57484G01N33/6893G01N2800/065G01N2333/4746
Inventor 陈永恒周敏泽李茂玉陈主初
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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