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A kind of general mri phantom preparation method
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A phantom and volume technology, applied in the fields of application, medical science, diagnosis, etc., can solve the problems of unclear ratio of required materials, change of solution concentration, complicated process, etc., to achieve a large adjustable range, simple operation, and time-consuming short effect
Active Publication Date: 2020-04-14
SHENZHEN INST OF ADVANCED TECH
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However, the heating of the oil bath is time-consuming and inefficient, which will change the concentration of the solution. The material needs to be filtered, and the process of using negative pressure suction to exhaust is also relatively complicated.
Moreover, there are many kinds of materials currently used to prepare phantoms, and the required material ratios are often unclear, and the material ratios required for different T1 and T2 relaxation times are also different, so it is impossible to efficiently prepare a general-purpose MRI phantom. mold
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Embodiment 1
[0026] Embodiment 1: normal myocardial phantom
[0027] Normal myocardial phantom T1 is 1174-1420ms; T2 is 39-58ms.
[0028] 1) Material
[0029] Nickelsulfate hexahydrate (NiSO 4 ·6H 2 O), agarose, pure water are production materials, measuring cylinder, beaker, stirring rod, electronic scale, microwave oven, ultrasonic oscillator are production tools, and centrifuge tubes are phantom moulds.
[0030] 2) Suppose T1=1280ms, T2=48ms
[0031] Substituting into formula (1) and formula (2), we can get
[0032]
[0033] The volume of water when preparing is 100mL, M NiSO4·6H2O =262.85, then bring into formula (3), formula (4) to obtain required agarose and nickelsulfate hexahydrate (NiSO 4 ·6H 2 The masses of O) are: 3.2929g and 14.538mg.
[0034] 3) Preparation of normal myocardial phantom
[0035] Take a graduated cylinder to measure 100ml of pure water, pour it into a beaker with an inner diameter of 10.5cm, a height of 16cm, and a capacity of 500mL; add 3.2929g of a...
[0038] Myocardial edema phantom T1 is 1520-1738ms; T2 is 65-80ms
[0039] 1) Material
[0040] Nickelsulfate hexahydrate (NiSO 4 ·6H 2 O), agarose, pure water are production materials, measuring cylinder, beaker, stirring rod, electronic scale, microwave oven, ultrasonic oscillator are production tools, and centrifuge tubes are phantom moulds.
[0041] 2) Suppose T1=1560ms, T2=68ms
[0042] Substituting into formula (1) (2) can get
[0043]
[0044] The volume of water when preparing is 100mL, M NiSO4·6H2O =262.85, then bring into formula (3), formula (4) to obtain required agarose and nickel sulfate hexahydrate (NiSO 4 ·6H 2 The quality of O) is: 2.2407g and 9.302mg
[0046] Take a graduated cylinder to measure 100ml of pure water, pour it into a beaker with an inner diameter of 10.5cm, a height of 16cm, and a capacity of 500mL; add 2.2407g of agarose, 9.302mg of n...
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Abstract
The present invention falls within the field of medical equipment quality inspection. Disclosed is a method for preparing a general-purpose MRI phantom material and a method for preparing a general-purpose MRI phantom. In the method for preparing a general-purpose MRI phantom material of the present invention, a ratio formula is established, wherein according to preset T1 and T2 values of the MRI phantom, the ratio of a desired material corresponding to a given T1 / T2 value can be directly calculated, and the range in which the T1 / T2 value can be adjusted is large. The method for preparing a general-purpose MRI phantom of the present invention comprises: according to preset T1 and T2 values of an MRI phantom and the volume of water, taking a prepared MRI phantom material and adding water thereto and mixing same, heating and dissolving same multiple times by means of microwaves, and placing same in an MRI phantom carrier to remove air bubbles by means of ultrasonic waves. In the method for preparing a general-purpose MRI phantom of the present invention, a phantom material can be directly configured as needed, making the efficiency high; heating is performed multiple times by means of a microwave oven, and therefore, the time consumption is short and less water is evaporated; there is no need to filter residue, and the concentration of a solution does not change; and ultrasonic waves are used to remove air bubbles, making operation simple.
Description
technical field [0001] The invention belongs to the field of medical equipment quality detection, and in particular relates to a preparation method of a general MRI phantom. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is to apply a radio frequency pulse of a specific frequency to the human body in a static magnetic field, so that the hydrogen protons in the human body are excited and magnetic resonance occurs. After the pulse is stopped, the protons generate MR signals during relaxation. MR signals are generated through processing processes such as receiving MR signals, spatial encoding, and image reconstruction. MRI has been applied to the imaging diagnosis of various systems of the whole body. The best effect is the brain, and its spinal cord, heart and great vessels, joint bones, soft tissues and pelvic cavity. For cardiovascular diseases, it can not only observe the anatomical changes of chambers, great blood vessels and ...
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