Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Frontotemporal dementia kit

A frontotemporal dementia and kit technology, applied in the field of kits, can solve the problems of incomplete clear etiology and pathogenesis, hidden and cumbersome onset of frontotemporal dementia, low detection cost, suitable for early screening, The effect of improving the diagnostic accuracy

Inactive Publication Date: 2019-04-12
天津安必森生物技术有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The onset of frontotemporal dementia is occult, and the etiology and pathogenesis are not completely clear; when identifying whether a patient has frontotemporal dementia, not only CT and MRI are needed for identification, but also clinical diagnosis and histopathological examination are required, which is very cumbersome; and currently There is no limited method of prevention yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0043] 1) The detection kit includes: a detection plate, a tracer solution, a positive control, a negative control, a sample diluent, a washing solution, and a chromogenic solution.

[0044] 2) Test plate preparation:

[0045] Immobilization of biomarker-specific antibodies by indirect coating. First, dilute the rabbit anti-mouse antibody to a concentration of 0.5ug / ml-20ug / ml with PBS buffer, then add 100ul of the antibody dilution to the wells of a 96-well microtiter plate, and incubate at room temperature for 2-3 hours Or incubate at low temperature (4-8°C) for 12 hours; wash the microplate wells with PBS+0.1% Tween 20 washing solution for 3-5 times; then, add 200ul of 2% BSA- PBS blocking solution, incubate at room temperature for 1-4 hours, then wash the microplate wells with PBS+0.1% Tween 20 washing solution for 3-5 times;

[0046] Secondly, prepare the following 12 biomarker-specific mouse antibody solutions with a concentration of 0.1ug / ml-10ug / ml with PBS buffer so...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the technical field of kits, and discloses a frontotemporal dementia kit. The frontotemporal dementia kit is internally provided with a type or a plurality of sets ofparallelly-arranged detecting plates; each detecting plate is provided with a plurality of detecting areas; the detecting areas comprise proteins of following biomarkers or corresponding receptor proteins or special antibody combinations; the biomarkers are Tau, Pick, TDP-43, NCls, Nlls and GCls; the Tau comprises any Tau of all Tau isomers; each detecting plate is an enzyme marking disc; and theproteins of the biomarkers or the corresponding receptor proteins or the special antibody combinations are directly or indirectly encased in the detecting areas. The kit diagnoses whether a subject suffers from frontotemporal dementia or not through simple in-vitro detecting, the various markers conduct detection and comparison simultaneously, thus the diagnostic accuracy rate is increased, and the frontotemporal dementia kit is especially suitable for early screening.

Description

technical field [0001] The invention relates to the technical field of kits, in particular to a kit for frontotemporal dementia. Background technique [0002] Frontotemporal dementia refers to a dementia syndrome in which middle-aged and elderly patients slowly develop personality changes, speech disorders, and abnormal behaviors. The main manifestation is localized brain atrophy. Atrophy is predominantly within the cerebral hemispheres, including most of the frontal, temporal, and insular regions, and the anterior parietal lobe, sometimes resulting in a "knife-like" atrophy. The onset of frontotemporal dementia is occult, and the etiology and pathogenesis are not completely clear; when identifying whether a patient has frontotemporal dementia, not only CT and MRI are needed for identification, but also clinical diagnosis and histopathological examination are required, which is very cumbersome; and currently There is no limited method of prevention. Contents of the invent...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6896
Inventor 常静瑶张亮田华李东梅
Owner 天津安必森生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com