Use of arsenic trioxide in preparation of medicines for treating advanced atherosclerosis

Abstract

The invention discloses use of arsenic trioxide in preparation of medicines for treating advanced atherosclerosis. The invention introduces the arsenic trioxide into the treatment of the advanced atherosclerosis for the first time, applies the mechanism of the arsenic trioxide promoting autophagy of macrophages in plaques, and treats the atherosclerosis by reducing the area of a lipid core and theinfiltration of inflammatory cells, increasing the thicknesses of fibrous caps and improving the stability of the plaques. The invention provides a novel non-invasive and safe treatment method for treating clinical patients with the advanced atherosclerosis in addition to invasive treatment such as surgery; after the arsenic trioxide is adopted, the occurrence rate of acute cardiovascular eventsis also reduced while the survival rate and the living quality of patients are improved, the manpower, material resources and financial resources which are consumed by the surgery are reduced, and themedical financial burden of the family and society is reduced. In summary, the invention provides novel medicines for the clinical treatment of the advanced atherosclerosis, and the occurrence of theacute cardiovascular events can be reduced, so that the use of the arsenic trioxide has certain clinical significance.

Description

technical field [0001] The invention relates to a new medicine for treating advanced atherosclerosis, in particular to the use of arsenic trioxide in the preparation of medicine for treating advanced atherosclerosis. The invention belongs to the technical field of medicine. Background technique [0002] At present, the number of people who die from cardiovascular disease in my country accounts for more than 40% of the total number of deaths from diseases every year, and most of them are people who die from coronary heart disease. And atherosclerosis (Atherosclerosis, AS) is the main factor leading to cardiovascular disease, so the prevention and treatment of atherosclerosis is the top priority, directly related to the health of Chinese residents. At present, the main clinical drugs are statin lipid-lowering drugs, as well as adjuvant drugs such as anticoagulant drugs and thrombolytic drugs. It has curative effect on early and mid-stage atherosclerosis, but has no good ther...

AI Technical Summary

Problems solved by technology

When the disease develops to an advanced stage, that is, the degree of vascular stenosis reaches more than 75%, the effect of drug treatment is not good, and the plaque at this time is extremely unstable and easy to rupture, leading to thrombosis, blocking blood vessels, and leading to serious acute cardiovascular events. Occurrence, at this time, the effect of drug treatment is not good, so we can only rely on surgery, such as recanalization, reconstruction or bypass grafting of stenotic or occluded arteries, and interventional treatment such as placement of stents in the blood vessel cavity is also feasible.

However, the operation is risky and may lead to the death of the patient, and the operation is invasive, which is not conducive to the recovery of the patient.

[0005] In summary, there is currently a lack of a specific drug that can replace surgery to treat advanced atherosclerosis. Therefore, it is urgent to find a new drug that can treat advanced atherosclerosis

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