8 results about "Fibrous cap" patented technology

The invention relates to a method for constructing a last-stage atherosclerotic plaque through additive manufacturing, and belongs to the technical field of tissue engineering. According to the method, firstly, cells are treated, then bio-ink for a fiber cap, bio-ink for a lipid nucleus and bio-ink for a suspension pool are prepared respectively, and then construction of the last-stage atherosclerotic plaque is completed through curing treatment. After a conditional culture solution and a stimulating factor are added, long-term in-vitro culture can be realized, and a real focus microenvironment can be simulated. The fibrous cap-lipid nucleus AS plaque constructed by the invention can maintain the stability and physiological function of the structure for a long time, and can accurately simulate hyperplasia, hypoxia, fat enrichment and inflammatory response of the AS plaque in the last stage.

The application discloses application of CCL3-AS1 in regulating stability of carotid artery plaque, overexpression of CCL3-AS1 induces inflammatory activity of macrophages and secretion of MMP9, promotes plaque rupture and thrombosis; on the contrary, knockdown of CCL3-AS1 inhibits inflammatory activity of macrophages and secretion of MMP9, reduces plaque rupture and thrombosis; in addition, the application also discloses that CCL3-AS1 enhances MMP9 mRNA stability by combining with hnRNP-K, thereby increasing MMP9 expression and secretion and degrading fibrous cap collagen. The application discloses important role of CCL3-AS1 in stability of carotid artery plaque and a molecular mechanism, provides a new diagnostic marker and a treatment target, not only provides a new direction for research on atherosclerosis related diseases, but also provides a new tool and a means for clinical diagnosis and treatment.

The invention discloses a carotid artery OCT fiber cap segmentation method, device and equipment and a storage medium, and the method comprises the steps: carrying out the weighting of an original carotid artery OCT image, a user click feature graph and a segmentation probability graph, and obtaining a weighted input feature; performing feature extraction on the input features by using a KAN trunk feature extraction module to obtain deep semantic features, dynamically adjusting a segmentation probability graph according to newly added clicks of a user, obtaining a modulated target probability graph, and generating original interaction information; and performing attention feature fusion on the deep semantic features and the original interaction information through a double-branch post-fusion strategy to obtain a segmentation prediction result of the current round, determining whether to iterate the segmentation prediction result according to user feedback information, and outputting a final segmentation result. The method can improve the boundary definition and precision of carotid artery OCT image fiber cap segmentation, supports real-time user interactive iterative correction, and improves the speed and efficiency of carotid artery OCT fiber cap segmentation.

The invention relates to the technical field of medical instruments, in particular to a heart model and coronary artery interventional operation training device.The heart model comprises a main body and a simulated blood vessel set, the blood vessel set is formed by sequentially connecting a coronary artery tube and first-level to third-level branch vein tubes, and the second-level branch vein tube is provided with a detachable lesion simulation module; the lesion simulation module is provided with simulation plaques such as calcification, a fiber cap or a lipid core and is used for simulating different stenosis lesions. The three-stage branch vein tube is additionally provided with a side branch tube and a multi-stage branch tube, so that the tortuosity and anatomy authenticity of the blood vessel are enhanced. The problems that an existing training device is simplified in branch, single in lesion and lack of key blood vessels and real tactile feedback are solved, the guide wire control ability and the operation proficiency of interventional doctors can be effectively improved, the learning period is shortened, and the clinical operation risk is reduced.

The application discloses a lower limb arterial occlusion segment sharp breakthrough positioning catheter, which comprises a catheter, one end of the catheter is in sealed connection with one end of a joint, the other end of the joint is provided with a guide wire inlet, pressure applying ports A and B are arranged along the longitudinal direction respectively, balloon pressure cavities are arranged on the upper and lower surfaces of the catheter respectively, the balloon pressure cavities are communicated with balloons A and B respectively, and the pressure applying ports A and B are communicated with the balloon pressure cavities; when the sharp breakthrough is performed on the occluded blood vessel segment, the breakthrough point is located at the center of the fiber cap, the sizes of the balloons A and B are controlled by increasing or decreasing the pressure respectively, then the balloons A and B press the guide wire cavity, the angle of the guide wire located in the guide wire cavity is changed, the breakthrough position can be better aligned, after the breakthrough, the front end of a wedge-shaped catheter is applied to perform the breakthrough, the blood flow is smoothly opened after the catheter is introduced, the blood flow opening is more in line with the operation principle, the blood vessel injury caused by the sharp breakthrough is reduced, the operation difficulty is reduced, and the operation success rate is improved.

Provided are a method, a device, and a program for accurately determining the risk of an atheroma. This method for determining the risk of an atheroma includes a condition determination step and a risk determination step. In the condition determination step, it is determined whether or not an atheroma shown in one or more tomographic images of a blood vessel of a patient which have been acquired by an imaging method utilizing optical interference satisfies the following conditions (a) and (b): (a) the atheroma has a fibrous cap having a thickness that is not more than a predetermined threshold value; and (b) the atheroma contains cholesterol crystals. In the risk determination step, when it has been determined that the atheroma satisfies the conditions (a) and (b), it is determined that the atheroma satisfying the conditions (a) and (b) has higher risk compared with an atheroma that satisfies one or neither of the conditions (a) and (b).

The invention relates to the technical field of image data processing, in particular to a multi-modal image fusion coronary lesion area recognition system, which comprises the following steps of: determining an abnormal area in a blood vessel wall based on structural analysis of the blood vessel wall and a blood vessel cavity in an optical coherence tomography image of a coronary artery of a user; determining a fiber cap region in the abnormal existence region according to the pixel gradient feature and the gray feature of the fiber cap, and recording an image region behind the fiber cap region in the blood vessel wall as the rear of the fiber cap; determining a lipid core abnormal region according to the signal weakening information behind the fiber cap in combination with the lipid distribution probability in the near infrared spectrum data; and determining a target abnormal region in the optical coherence tomography image according to the image features of the intravascular ultrasonic image of the coronary artery of the user for the lipid core abnormal region. Through the technical scheme of the invention, the identification accuracy of the focus is improved, and the focus area is segmented more accurately.

The invention discloses a construction method of an atherosclerotic advanced vulnerable plaque rapid modeling gene mouse, and belongs to the technical field of biology. According to the method, an apolipoprotein E gene (apolipoprotein E, ApoE) knockout mouse which does not need to be subjected to induction and is specifically knocked out from an insulin-like growth factor 1 (IGF1) gene tissue is obtained through a hybridization method and a Cre-LoxP technology. According to the invention, a mononuclear phagocyte system specific knockout IGF1 gene is introduced into an ApoE- / -mouse genome for the first time, the characteristics of two genotypes are combined, and atherosclerotic advanced vulnerable plaque with the characteristics of large lipid core, a large number of inflammatory cells, typical thin fibrous caps, negative vascular remodeling and the like can be formed without induction; and the method is simple and easy to implement and good in repeatability, and the molding time is shortened.