4 results about "Fibrous cap" patented technology

The application discloses application of CCL3-AS1 in regulating stability of carotid artery plaque, overexpression of CCL3-AS1 induces inflammatory activity of macrophages and secretion of MMP9, promotes plaque rupture and thrombosis; on the contrary, knockdown of CCL3-AS1 inhibits inflammatory activity of macrophages and secretion of MMP9, reduces plaque rupture and thrombosis; in addition, the application also discloses that CCL3-AS1 enhances MMP9 mRNA stability by combining with hnRNP-K, thereby increasing MMP9 expression and secretion and degrading fibrous cap collagen. The application discloses important role of CCL3-AS1 in stability of carotid artery plaque and a molecular mechanism, provides a new diagnostic marker and a treatment target, not only provides a new direction for research on atherosclerosis related diseases, but also provides a new tool and a means for clinical diagnosis and treatment.

The application discloses a lower limb arterial occlusion segment sharp breakthrough positioning catheter, which comprises a catheter, one end of the catheter is in sealed connection with one end of a joint, the other end of the joint is provided with a guide wire inlet, pressure applying ports A and B are arranged along the longitudinal direction respectively, balloon pressure cavities are arranged on the upper and lower surfaces of the catheter respectively, the balloon pressure cavities are communicated with balloons A and B respectively, and the pressure applying ports A and B are communicated with the balloon pressure cavities; when the sharp breakthrough is performed on the occluded blood vessel segment, the breakthrough point is located at the center of the fiber cap, the sizes of the balloons A and B are controlled by increasing or decreasing the pressure respectively, then the balloons A and B press the guide wire cavity, the angle of the guide wire located in the guide wire cavity is changed, the breakthrough position can be better aligned, after the breakthrough, the front end of a wedge-shaped catheter is applied to perform the breakthrough, the blood flow is smoothly opened after the catheter is introduced, the blood flow opening is more in line with the operation principle, the blood vessel injury caused by the sharp breakthrough is reduced, the operation difficulty is reduced, and the operation success rate is improved.

Provided are a method, a device, and a program for accurately determining the risk of an atheroma. This method for determining the risk of an atheroma includes a condition determination step and a risk determination step. In the condition determination step, it is determined whether or not an atheroma shown in one or more tomographic images of a blood vessel of a patient which have been acquired by an imaging method utilizing optical interference satisfies the following conditions (a) and (b): (a) the atheroma has a fibrous cap having a thickness that is not more than a predetermined threshold value; and (b) the atheroma contains cholesterol crystals. In the risk determination step, when it has been determined that the atheroma satisfies the conditions (a) and (b), it is determined that the atheroma satisfying the conditions (a) and (b) has higher risk compared with an atheroma that satisfies one or neither of the conditions (a) and (b).

The invention relates to the technical field of image data processing, in particular to a multi-modal image fusion coronary lesion area recognition system, which comprises the following steps of: determining an abnormal area in a blood vessel wall based on structural analysis of the blood vessel wall and a blood vessel cavity in an optical coherence tomography image of a coronary artery of a user; determining a fiber cap region in the abnormal existence region according to the pixel gradient feature and the gray feature of the fiber cap, and recording an image region behind the fiber cap region in the blood vessel wall as the rear of the fiber cap; determining a lipid core abnormal region according to the signal weakening information behind the fiber cap in combination with the lipid distribution probability in the near infrared spectrum data; and determining a target abnormal region in the optical coherence tomography image according to the image features of the intravascular ultrasonic image of the coronary artery of the user for the lipid core abnormal region. Through the technical scheme of the invention, the identification accuracy of the focus is improved, and the focus area is segmented more accurately.