Use of arsenic trioxide in the preparation of drugs for treating advanced atherosclerosis

Abstract

The invention discloses the use of arsenic trioxide in the preparation of medicine for treating advanced atherosclerosis. The present invention introduces arsenic trioxide into the treatment of advanced atherosclerosis for the first time, uses its mechanism of promoting autophagy of macrophages in plaques, reduces the area of ​​lipid core and the infiltration of inflammatory cells, increases the thickness of fibrous cap, and promotes plaque Block stability, to treat atherosclerosis. The proposal of the present invention provides a new type of non-invasive and safe treatment method for the treatment of clinical patients with advanced atherosclerosis in addition to invasive treatments such as surgery. While improving the survival rate and quality of life of patients, it also reduces the risk of acute cardiovascular disease. It reduces the incidence of incidents, reduces the manpower, material and financial resources consumed by surgery, and reduces the medical and economic burden on families and society. In summary, the present invention provides a new drug for the clinical treatment of advanced atherosclerosis, which can reduce the occurrence of acute cardiovascular events and has certain clinical significance.

Description

technical field [0001] The invention relates to a new medicine for treating advanced atherosclerosis, in particular to the use of arsenic trioxide in the preparation of medicine for treating advanced atherosclerosis. The invention belongs to the technical field of medicine. Background technique [0002] At present, the number of people who die from cardiovascular disease in my country accounts for more than 40% of the total number of deaths from diseases every year, and most of them are people who die from coronary heart disease. And atherosclerosis (Atherosclerosis, AS) is the main factor leading to cardiovascular disease, so the prevention and treatment of atherosclerosis is the top priority, directly related to the health of Chinese residents. At present, the main clinical drugs are statin lipid-lowering drugs, as well as adjuvant drugs such as anticoagulant drugs and thrombolytic drugs. It has curative effect on early and mid-stage atherosclerosis, but has no good ther...

AI Technical Summary

Problems solved by technology

When the disease develops to an advanced stage, that is, the degree of vascular stenosis reaches more than 75%, the effect of drug treatment is not good, and the plaque at this time is extremely unstable and easy to rupture, leading to thrombosis, blocking blood vessels, and leading to serious acute cardiovascular events. Occurrence, at this time, the effect of drug treatment is not good, so we can only rely on surgery, such as recanalization, reconstruction or bypass grafting of stenotic or occluded arteries, and interventional treatment such as placement of stents in the blood vessel cavity is also feasible.

However, the operation is risky and may lead to the death of the patient, and the operation is invasive, which is not conducive to the recovery of the patient.

[0005] In summary, there is currently a lack of a specific drug that can replace surgery to treat advanced atherosclerosis. Therefore, it is urgent to find a new drug that can treat advanced atherosclerosis

Images