Neural restoration film and preparation method and application thereof

A nerve repair and fibrous membrane technology, applied in the fields of medical science, prostheses, coatings, etc., can solve problems such as unfavorable nerve repair and disordered growth of nerve cells, and achieve the goal of promoting directional growth, improving growth rate and synapse. Morphology, the effect of promoting recovery

Active Publication Date: 2019-05-17
宁波光远致信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nerve guide prepared by the above method has high mechanical strength, strong flexibility, and long degradation cycle, and can be well applied to the regeneration and repair of damaged nerves, but the nerve guide used to repair damaged nerves During the process, nerve cells grow disorderly, which is not conducive to the repair of nerves.

Method used

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  • Neural restoration film and preparation method and application thereof
  • Neural restoration film and preparation method and application thereof
  • Neural restoration film and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] This embodiment provides a nerve repair membrane, which is prepared by the following method:

[0072] (1) Preparation of electrospinning stock solution:

[0073] The polylactic acid-glycolic acid copolymer (M w =80000) and multi-walled carbon nanotubes are dissolved in hexafluoroisopropanol to obtain a suspension, which is continuously stirred for 24h, followed by ultrasonic treatment for 1h to obtain a polymer with a mass fraction of 20%, multi-bi The mass fraction of carbon nanotubes was 1.6% in the electrospinning stock solution.

[0074] (2) Preparation of fiber membrane:

[0075] Inject the electrospinning stock solution obtained in step (1) into the syringe, inject the electrospinning stock solution at a speed of 2mL / h under the action of the propulsion pump of the electrospinning equipment, and carry out electrospinning at a loading voltage of 15kV, using a metal Rotate the receiving tray to receive the polylactic acid-glycolic acid copolymer fiber membrane mi...

Embodiment 2

[0080] The difference from Example 1 is that step (3) is not performed.

Embodiment 3

[0082] The difference from Example 1 is that polylactic acid-glycolic acid copolymer is replaced by polylactic acid (Mw=80000).

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Abstract

The invention relates to a neural restoration film and a preparation method and application thereof. The neural restoration film comprises a polymer fibrous film mixed with carbon nano tubes. The polymer is biodegradable. The polymer fibrous film mixed with the carbon nano tubes has the single directionality. The method comprises the following steps that 1, the polymer and the carbon nano tubes are dissolved in a solvent, and an electrospinning stock solution is obtained; 2, the electrospinning stock solution is subjected to electrostatic spinning, the polymer fibrous film mixed with the carbon nano tubes is obtained, that is, the neural restoration film is obtained. The neural restoration film can promote directional growth of nerve cells, and has an excellent restoration effect on damaged nerves.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nerve repair membrane and its preparation method and application. Background technique [0002] Peripheral nerve injury is a common disabling condition that results in loss of sensation and motor dysfunction. Today's clinical treatment has applied various methods to the treatment to restore the loss of function. End-to-end splices can be used for short nerve injuries, whereas for distant nerve deficits a nerve graft is needed to bridge the transected nerve. Nerve autografting is currently the clinical standard for treating peripheral nerve injuries with a gap of 5-10 mm, however this approach requires removal of a segment of the nerve from a secondary site in the body, which causes additional surgical pain, as well as sensory function at the donor site lost. Furthermore, disadvantages such as limited donor resources, insufficient donor nerve length, and diameter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/08A61L27/34A61L27/18A61F2/02
Inventor 许杉杉韩志超张诺滋
Owner 宁波光远致信生物科技有限公司
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