Hypoglycemic substance aiming at hyperglycemia during pregnancy, application and preparation method of substance

A technology of fat-soluble substances and seeds, which is applied in the field of hypoglycemic substances and can solve problems such as side effects

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs that can treat general hyperglycemia. Although these drugs also have a certain degree of side effects, for patients with general hyperglycemia, the benefits of the drugs outweigh the side effects, so they can be used alone or in combination

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0025] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, heat to 120°C under 0.01atm vacuum to recover ethanol; then add 5kg of ether as unsaponifiable extractant for extraction, separate the upper layer extract, and heat to 85°C under 0.01atm vacuum to recover the extractant , to obtain 400g liquid substance, namely the present invention Hevea brasiliensis The unsaponifiable matter of the fat-soluble part of the seed.

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Embodiment 2

[0030] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0031] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 440g remaining liquid matter and be exactly the present invention Hevea brasiliensis The unsaponifiable matter...

Embodiment 3

[0036] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and the fat-soluble substance of 15kg seeds is extruded.

[0037] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 450g remaining liquid matter and be exactly the present invention Hevea brasiliensi...

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Abstract

The invention discloses a hypoglycemic substance aiming at hyperglycemia during pregnancy, an application and a preparation method of the substance. The substance is an unsaponifiable substance of a fat-soluble substance of a seed of a plant Hevea brasiliensis. The method includes taking the fat-soluble substance extracted from the seed of the Hevea brasiliensis as a raw material to carry out a saponification reaction; and then separating and purifying the substance which does not participate in the saponification reaction. The substance can be applied to medicines, health foods and foods, andcan be used for reducing blood sugar of patients with hyperglycemia during pregnancy, has no side effect, and is very safe for mothers and infants.

Description

technical field [0001] The invention discloses a hypoglycemic substance for hyperglycemia during pregnancy, its application and its preparation method, belonging to the fields of medicine and food. Background technique [0002] There are two types of diabetes in pregnant women during pregnancy. One is diabetes diagnosed before pregnancy, which is called "diabetes combined with pregnancy"; the other is normal glucose metabolism or potential impaired glucose tolerance before pregnancy, which occurs or is diagnosed during pregnancy This type of diabetes is called gestational hyperglycemia, also known as gestational diabetes. Hyperglycemia during pregnancy accounts for more than 80% of pregnant women with diabetes, and the incidence rate is reported to be 1% to 14% in various countries in the world. In my country, the incidence rate is 1% to 5%. Most patients with hyperglycemia during pregnancy can return to normal after delivery, but the chances of suffering from type II diabe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P3/10A61P15/00A61K131/00
Inventor 徐爽
Owner 徐爽
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