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Hypotensive substance aiming at hypertension during pregnancy, application and preparation method thereof

A technology of fat-soluble substances and seeds, applied in the field of hypotensive substances, can solve the problems of limited antihypertensive effect of magnesium sulfate and no available drugs

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antihypertensive effect of magnesium sulfate is very limited
[0007] Generally speaking, patients with hypertension during pregnancy are still in the predicament of having no drugs available, so they can only induce labor in advance or cesarean section

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0027] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, heat to 120°C under 0.01atm vacuum to recover ethanol; then add 5kg of ether as unsaponifiable extractant for extraction, separate the upper layer extract, and heat to 85°C under 0.01atm vacuum to recover the extractant , to obtain 400g liquid substance, namely the present invention Hevea brasiliensis The unsaponifiable matter of the fat-soluble part of the seed.

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Embodiment 2

[0032] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0033] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 440g remaining liquid matter and be exactly the present invention Hevea brasiliensis The unsaponifiable matter...

Embodiment 3

[0038] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and the fat-soluble substance of 15kg seeds is extruded.

[0039] 10kg Hevea brasiliensisThe fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 450g remaining liquid matter and be exactly the present invention Hevea brasiliensis...

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Abstract

The invention discloses a hypotensive substance aiming at hypertension during pregnancy, an application and a preparation method thereof. The substance is an unsaponifiable substance of a fat-solublesubstance of a seed of a plant Hevea brasiliensis. The method includes taking the fat-soluble substance extracted from the seed of the Hevea brasiliensis as a raw material to carry out a saponification reaction; and then separating and purifying the substance which does not participate in the saponification reaction. The substance can be applied to medicines, healthcare foods and foods, can be used for reducing blood pressure of patients with hypertension during pregnancy, has no side effect and is very safe for mothers and infants.

Description

technical field [0001] The invention discloses a blood pressure-lowering substance aimed at hypertension during pregnancy, its application and its preparation method, belonging to the fields of medicine and food. Background technique [0002] Hypertensive disorders of pregnancy are specific diseases of pregnant women, including gestational hypertension, preeclampsia, eclampsia, chronic hypertension complicated by preeclampsia, and chronic hypertension. The incidence rate is 9.4% in my country, and 7% to 12% in foreign reports. The disease seriously affects the health of mothers and infants, and is one of the main causes of maternal and perinatal morbidity and death. [0003] Its clinical manifestations include high blood pressure, edema, and proteinuria in pregnant women around 20 weeks of pregnancy. In mild cases, it may be asymptomatic or mild dizziness, and blood pressure may increase slightly, accompanied by edema or mild proteinuria; in severe cases, headache, vertigo,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P15/00A61P9/12A61K131/00
Inventor 徐爽
Owner 徐爽
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