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Composition and method for inducing astrocyte to become functional nerve cells

An astrocyte and composition technology, which is applied to animal cells, nervous system cells, vertebrate cells, etc., to achieve the effect of preventing and treating brain degeneration and brain damage

Pending Publication Date: 2019-06-11
SOUTH CHINA NORMAL UNIVERSITY
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But eventually the glial scars they formed prevented the neurons from regenerating

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  • Composition and method for inducing astrocyte to become functional nerve cells
  • Composition and method for inducing astrocyte to become functional nerve cells

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Embodiment Construction

[0020] The drugs screened in the present invention include SB431542, Repsox, LDN193189, dorsomorphin, DAPT, CHIR99021, Thiazovivin, Y27632, Smoothened agoinist (SAG), purmorphamine, TTNPB, retinoic acid, valproic acid (VPA), forskolin, ISX9 and more than twenty kinds Small molecule drugs related to glial cell to neuron transformation, growth factors such as FGF2, BDNF, GDNF, EGF, etc. Screen through different compound combinations. After screening by the isolated cell culture platform, it is finally determined that the existing optimal combination can transform glial cells into neurons, and the other groups either have severe apoptosis or have no change compared with the control group. Therefore, it was finally determined that these six small molecule compounds SB431542, CHIR99021, Forskolin, Y27636, DAPT, VPA and a growth factor FGF2 were tested in living animals and found that activated glial cells can also be transformed into functional glial cells in vivo. of neurons.

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Abstract

The invention discloses a composition and method for inducing astrocyte to become functional nerve cells. Through research, the inventor finds that when GSK-3 beta, TGF-beta and BMP signal channels are acted, and astrocyte signal channels are restrained or closed, the astrocyte can be sufficiently induced to become functional nerve cells. Through converting activated glial cells and colloid cicatrice into the functional nerve cells, brain degeneration and brain damage can be prevented and treated, and innovation of traditional anti-ageing health-care product industry and great brain disease treatment can be driven possibly.

Description

technical field [0001] The invention relates to a method for inducing cells, in particular to a composition and a method for inducing astrocytes to become functional neurons. Background technique [0002] When the brain is damaged or diseased, neurons usually die or degenerate, and astrocytes are activated and proliferate, known as stressed astrocytes. These stressed astrocytes initially build a protective wall that stops bacteria and cytokines and toxins from further invading surrounding healthy tissue. But in the end the glial scar they formed prevented the neurons from regenerating. [0003] How to induce astrocytes into functional neurons for nerve repair is a challenging work. Contents of the invention [0004] The purpose of the present invention is to provide a composition and method for inducing astrocytes to become functional neurons. [0005] The technical scheme that the present invention takes is: [0006] A composition for inducing astrocytes to become fun...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0793
Inventor 吴冈义陈世缘霍清伟
Owner SOUTH CHINA NORMAL UNIVERSITY
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