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Method for measuring homonuclear indirect coupling network

An indirect, network technology, applied in the field of nuclear magnetic resonance spectroscopy, can solve the problems of increasing the complexity of the spectrum, interaction, small homonuclear coupling constant, etc., and achieve the effect of simple and reliable accurate measurement.

Active Publication Date: 2019-06-14
XIAMEN UNIV
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The complexity of the spectrum is increased due to the interaction between spins, the small homonuclear coupling constant, and the crowding of individual spin peaks

Method used

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  • Method for measuring homonuclear indirect coupling network
  • Method for measuring homonuclear indirect coupling network
  • Method for measuring homonuclear indirect coupling network

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Embodiment Construction

[0028] The method proposed by the invention can not only overcome the shortcomings of the traditional J spectrum, directly obtain the pair and network information of the excited nucleus, but also realize F2-dimensional decoupling, and further improve the resolution of the spectrum. The method of the present invention is simple to operate, and the method of the present invention only needs to import the compiled pulse sequence and the corresponding data post-processing code in text format on the spectrometer, without special hardware devices, and can be applied to any conventional nuclear magnetic resonance spectrometer, so it is Correlative molecular structure analysis provides a simple and reliable method.

[0029] The character comparison table used in the present invention refers to the following table 1:

[0030] Table 1

[0031]

[0032]

[0033] Each step in the specific implementation process of the present invention is as follows:

[0034] Step 1, sample loadin...

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Abstract

The invention provides a method for measuring a homonuclear indirect coupling network. Through the design of a pulse sequence, a selective pulse, a PSYCHE module and three-dimensional data sampling and splicing are utilized to finally obtain a two-dimensional spectrum representing the homonuclear indirect coupling network, wherein one dimension only displays spin-chemical shift information in a coupling network, no coupling signals exist, and the other dimension displays spin and interesting spin indirect coupling constants; and a simple and reliable method is provided for accurate measurementof the indirect coupling information. According to the method in the invention, only a compiled pulse sequence and the corresponding data postprocessing codes need to be imported on the spectrometerin a text format without the need of special hardware devices, and the method can be applied to any conventional nuclear magnetic resonance spectrometer.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance (NMR, Nuclear Magnetic Resonance) spectroscopy detection method, in particular to a method for measuring homonuclear indirect coupling information, and the provided two-dimensional spectrum displays the chemical shifts of all spins in the coupling network of interest in one dimension, all spins in the network and the indirect coupling constants of the spin of interest are shown in another dimension, the resolution of the spectrum and the precision of the measurement are greatly improved. Background technique [0002] Homonuclear scalar coupling provides crucial information for conformation and structure elucidation of organic chemistry and biomolecules. Due to the interaction between spins, the small homonuclear coupling constant, and the crowding of individual spin peaks increase the complexity of the spectrum. To this end, it is necessary to overcome the influence of spins in the indirect couplin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
Inventor 林玉兰苏健伟陈忠
Owner XIAMEN UNIV
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