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Preparation of silk fibroin nanoparticles coated with manganese dioxide

A technology of silk fibroin and nanoparticles, which is applied in the preparation method of peptides, organic chemistry, chemical instruments and methods, etc., can solve the problems of easy sedimentation, influence of material appearance and performance, uneven distribution of nanoparticles, etc., and achieve good photothermal High performance, strong application value, and high biological safety

Pending Publication Date: 2019-07-26
SOUTHWEST UNIVERSITY
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Problems solved by technology

However, the composite materials prepared by the blending method have uneven distribution of nanoparticles, easy sedimentation, and the appearance and performance of the material are affected.

Method used

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  • Preparation of silk fibroin nanoparticles coated with manganese dioxide
  • Preparation of silk fibroin nanoparticles coated with manganese dioxide
  • Preparation of silk fibroin nanoparticles coated with manganese dioxide

Examples

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Embodiment 1

[0028] Example 1 Preparation of silk fibroin nanoparticles coated with manganese dioxide

[0029] The synthetic flow chart of the silk fibroin nanoparticle that encapsulates manganese dioxide is as follows figure 1 Shown, comprise following preparation steps:

[0030] (1) Extraction of silk fibroin: take silk cocoons and use scissors to cut the cocoons along the axis of symmetry, take out the silkworm chrysalis, and then cut the silk cocoons into one-eighth pieces. Take 100 grams of cocoon slices and add them to 2 liters of 0.5% sodium carbonate solution, and cook for 30 minutes in a boiling state. Then pour off the sodium carbonate solution, and wash the silk fibroin repeatedly with secondary water. The rinsed silk fibroin was placed in a blast drying oven at 35 degrees Celsius for 12 hours.

[0031] (2) Redissolution of silk fibroin: configure calcium chloride, ethanol and 50 grams of aqueous solution at a molar ratio of 1:2:8, add 2 grams of silk fibroin prepared in step...

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Abstract

The invention relates to the field of synthesis of nanomaterials, in particular to a method for synthesizing silk fibroin nanoparticles and a method for rapidly and gently encapsulating manganese dioxide onto the surfaces of silk fibroin nanoparticles inspired by biomineralization. The method specifically includes the following steps: (1) silk fibroin extraction and silkworm cocoon degumming; (2)self-assembly of the silk fibroin nanoparticles in an acetone solution; (3) utilizing silk fibroin balls as both a template and a reducing agent to react with a potassium permanganate solution to produce manganese dioxide in situ on the surfaces of the silk fibroin nanoparticles. A resulting multifunctional nano platform has photothermal performances, drug delivery capabilities, catalytic activitysimilar to catalase and T1-weighted nuclear magnetic resonance imaging capabilities. The preparation has great potential for application in the fields of biomedicine and other areas of social economy.

Description

technical field [0001] The invention relates to the field of synthesis of nanomaterials, more specifically to a synthesis method of silk fibroin nanoparticles and a method inspired by biomineralization to quickly and gently wrap manganese dioxide on the surface of silk fibroin nanoparticles. Background technique [0002] Silkworm is one of the earliest natural animal proteins used by humans. The silkworm has been cultured in my country for thousands of years. As a natural fiber with excellent performance, silk has been used in the textile industry. In recent years, with the research on the performance and application of silk and the progress of protein engineering, silk, as a high-purity crystalline protein, has attracted people in biomaterials and fine chemicals because of its good biocompatibility and breathable oxygen permeability. widespread attention. [0003] Silk is composed of two parts: fibroin and sericin. Sericin is coated on the outside of silk fibroin, accounti...

Claims

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Application Information

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IPC IPC(8): C07K17/14C07K14/435C07K1/34
CPCC07K17/14C07K14/43586
Inventor 薛鹏杨瑞昊康跃军张蕾
Owner SOUTHWEST UNIVERSITY
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