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Animal model of hypertension and construction method and application of animal model

A technology of animal model and construction method, which is applied in the field of medicine, can solve problems such as the great influence on the structure and function of the heart, and achieve the effect of high modeling rate

Inactive Publication Date: 2019-08-27
山东科诺德生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obesity is significantly related to the incidence of hypertension, and obesity-related hypertension has a greater impact on the structure and function of blood vessels, heart, and animal models of hypertension combined with obesity have not been reported

Method used

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  • Animal model of hypertension and construction method and application of animal model
  • Animal model of hypertension and construction method and application of animal model
  • Animal model of hypertension and construction method and application of animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A construction method of an animal model of hypertension is as follows:

[0026] 1. Experimental materials and instruments

[0027] 1.1 Select 32 7-week-old spontaneously hypertensive rats, half male and half male, with body weight between 120±10g;

[0028] 1.2 Instruments: LXJ-Ⅱ centrifugal sedimentation machine (Shanghai Third Analytical Instrument Factory); LX20 automatic biochemical analyzer (Beckman Coulter, USA); BP-6 animal non-invasive blood pressure tester (Chengdu Taimeng Technology Co., Ltd. Company); automatic blood cell analyzer (Shenzhen Mindray Biomedical Electronics Co., Ltd.); ACS-6 electronic scale (Shandong Jinan Fenghua Electronic Scale Co., Ltd.); serum ultrafilter (Shanghai Dehong Biomedical Technology Development Co., Ltd. ); Quantitative liquid taker (Shanghai Jinlin Biochemical Reagent Instrument Factory);

[0029] 2. Experimental method

[0030] 2.1 Modeling SHR rats, half male and half male, 7 weeks old, weighing 120±10g, 32 rats. 8 as nor...

Embodiment 2

[0041] A kind of hypertension animal model and its construction method and application are as follows:

[0042] 1. Experimental materials and instruments

[0043] 1.1 Select 32 7-week-old spontaneously hypertensive rats, half male and half male, with body weight between 120±10g;

[0044] 1.2 Instruments: LXJ-Ⅱ centrifugal sedimentation machine (Shanghai Third Analytical Instrument Factory); LX20 automatic biochemical analyzer (Beckman Coulter, USA); BP-6 animal non-invasive blood pressure tester (Chengdu Taimeng Technology Co., Ltd. Company); automatic blood cell analyzer (Shenzhen Mindray Biomedical Electronics Co., Ltd.); ACS-6 electronic scale (Shandong Jinan Fenghua Electronic Scale Co., Ltd.); serum ultrafilter (Shanghai Dehong Biomedical Technology Development Co., Ltd. ); Quantitative liquid taker (Shanghai Jinlin Biochemical Reagent Instrument Factory);

[0045] 2. Experimental method

[0046] 2.1 Modeling SHR rats, half male and half male, 7 weeks old, weighing 120...

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Abstract

The invention relates to the technical field of medicament, and provides an animal model of hypertension and a construction method and application of the animal model. The animal model of hypertensioncan be used for studying pathogenesis of the hypertension and rules of occurrence and development of complications. The construction method includes: on the basis of a spontaneously hypertensive rat,feeding high-sugar and high-fat diets to the model rat, wherein every high-sugar and high-fat diet comprises, by weight, 47.9-49 parts of normal feed, 2-5 parts of cholesterol, 20-25 parts of streptozotocin, 20-25 parts of lard oil, 0.1-5 parts of sodium tauroglycocholate and 10-15 parts of yolk powder; after feeding the rat for 12 weeks, constructing a hypertensive rat model. Biochemical criterions of the constructed hypertensive rat model include systolic pressure, diastolic pressure, blood glucose and blood fat, and blood fat inspection indexes include serum total cholesterol, triacylglycerol, high-density lipoprotein and low-density lipoprotein. The construction method of the animal model is simple to operate, convenient to control and high in model forming rate.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an animal model of hypertension and its construction method and application. Background technique [0002] Hypertension is the most important risk factor for cardiovascular and cerebrovascular morbidity and death in the Chinese population, and is a major public health problem worldwide. Hypertension can cause diseases in many organs of the body, among which stroke and myocardial infarction are the most common, and become the main risk factor for human disability or death. For a long time, many scholars have devoted themselves to the animal experimental research of hypertension, which has played an important role in the study of the pathogenesis of hypertension and the occurrence and development of complications. [0003] Diabetes with hypertension is a common clinical disease phenomenon. Although there are many animal models of hypertension and diabetes in basic research, anima...

Claims

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 苏爱民陈文征陈博源郝连起李苗苗
Owner 山东科诺德生物医药科技有限公司
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