A kind of multilayer gradient biofilm and preparation method thereof
A biofilm and gradient technology, used in drug delivery, pharmaceutical formulations, prostheses, etc., can solve the problems of excessive degradation speed and insufficient mechanical properties of natural polymers, and achieve high tensile strength, good biocompatibility, The effect of good mechanical properties
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Embodiment 1
[0057] A kind of multilayer gradient biofilm that preferred embodiment of the present invention provides, its preparation method specific steps are as follows:
[0058] Dissolve 0.06g of polycaprolactone and 0.54g of gelatin in 5mL of trifluoroethanol under stirring at 25°C, add 0.015mL of acetic acid after they are completely dissolved and stir well to obtain a spinning polycaprolactone / gelatin Solution A: Dissolve 0.30g polycaprolactone and 0.30g gelatin in 5mL trifluoroethanol under stirring at 25°C, add 0.015mL acetic acid after they are completely dissolved and stir well to obtain polycaprolactone / gelatin spinning solution B; at 25°C, 0.0325g of nano-hydroxyapatite was added to 5mL of trifluoroethanol solution, ultrasonically oscillated at 350W for 60min, and then 0.455g of polycaprolactone and 0.195g of polycaprolactone were mixed under stirring Gelatin was dissolved in trifluoroethanol solution of hydroxyapatite to prepare spinning solution C of nano-hydroxyapatite / poly...
Embodiment 2
[0061] A kind of multilayer gradient biofilm that preferred embodiment of the present invention provides, its preparation method specific steps are as follows:
[0062] Dissolve 0.18g of polycaprolactone and 0.42g of gelatin in 5mL of trifluoroethanol under stirring at 25°C, add 0.015mL of acetic acid after they are completely dissolved and stir well to obtain a spinning polycaprolactone / gelatin Solution A: Dissolve 0.30g polycaprolactone and 0.30g gelatin in 5mL trifluoroethanol under stirring at 25°C, add 0.015mL acetic acid after they are completely dissolved and stir well to obtain polycaprolactone / gelatin Spinning solution B; at 25°C, add 0.065g nano-hydroxyapatite to 5mL trifluoroethanol solution, ultrasonically shake at 350W for 60min, then mix 0.455g polycaprolactone and 0.195g polycaprolactone under stirring Gelatin was dissolved in trifluoroethanol solution of hydroxyapatite to prepare spinning solution C of nano-hydroxyapatite / polycaprolactone / gelatin. Under the co...
Embodiment 3
[0065] A kind of multilayer gradient biofilm that preferred embodiment of the present invention provides, its preparation method specific steps are as follows:
[0066] Dissolve 0.30g of polycaprolactone and 0.30g of gelatin in 5mL of trifluoroethanol under stirring at 25°C, add 0.015mL of acetic acid after they are completely dissolved and stir well to obtain the spinning polycaprolactone / gelatin Solution A: Dissolve 0.30g polycaprolactone and 0.30g gelatin in 5mL trifluoroethanol under stirring at 25°C, add 0.015mL acetic acid after they are completely dissolved and stir well to obtain polycaprolactone / gelatin spinning solution B; at 25°C, add 0.0975g nano-hydroxyapatite to 5mL trifluoroethanol solution, ultrasonically shake at 350W for 60min, then mix 0.455g polycaprolactone and 0.195g polycaprolactone under stirring Gelatin was dissolved in trifluoroethanol solution of hydroxyapatite to prepare spinning solution C of nano-hydroxyapatite / polycaprolactone / gelatin. Under the...
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