Composition for biological fluid purification

A technology of biological fluids and compositions, applied in the direction of drug combinations, alkali metal compounds, alkali metal oxides/hydroxides, etc., can solve the problems of toxicity and limited effect

Active Publication Date: 2019-09-24
BEACON MEDCARE HK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If not properly removed, these metabolic waste products can accumulate in the body and become toxic
Although hemodialysis or peritoneal dialysis is currently used to reduce the content of met

Method used

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  • Composition for biological fluid purification
  • Composition for biological fluid purification
  • Composition for biological fluid purification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0309] The preparation of embodiment 1 peritoneal dialysis fluid

[0310] Measure a certain volume of commercially available basic peritoneal dialysis solution under sterile conditions, place it in a high-pressure steam sterilized container, add a certain amount of sterilized toxin removal reagent, shake and shake to mix evenly and seal it, and ultrasonicate in a water bath at 25°C (50Hz, 40KW, 30 minutes), placed in a 37°C water-bath shaker (100rpm, 30 minutes), and then sterilized by a suitable method such as high-temperature steam. Shake again before use.

Embodiment 2

[0311] The effect of the amount of embodiment 2 toxin removal reagent on the osmotic pressure of different peritoneal dialysates

Embodiment 2-1

[0312] Embodiment 2-1: add the icodextrin peritoneal dialysate of different amounts of toxin removal reagents (% by weight is weight to volume ratio)

[0313] The osmolarity of the peritoneal dialysates obtained by adding different amounts of toxin-removing reagents was measured using the freezing point depression method.

[0314] Table 1. Osmolality of commercially available icodextrin peritoneal dialysis solutions containing different amounts of added toxin removal reagents

[0315]

[0316] It can be seen from Table 1 that for the Kollidon CL-SF, Soluplus and micropowder silica gel groups, the osmotic pressure increases slightly with the increase of the added amount. However, for all groups, the osmotic pressure of the peritoneal dialysis solution obtained by adding different amounts of the toxin removal reagents above met the requirements of the peritoneal dialysis solution. To reduce dehydration that may be caused by peritoneal dialysis, the amount of toxin removal ag...

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PUM

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Abstract

The present application discloses a composition for biological fluid purification (e.g. hemodialysis and peritoneal dialysis). The composition comprises a penetrant and a toxin removal reagent, wherein the toxin removal reagent is capable of removing toxins in biological fluid under osmotic exchange conditions. The present application also provides a dialysis solution, a kit, etc. containing the composition, a method using the composition to remove the toxins in the biological fluid, and a method of treating diseases associated with the toxins.

Description

[0001] field of invention [0002] The invention relates to a novel composition, device and biological fluid purification method which can be used for biological fluid purification. Background technique [0003] In normal organisms, various toxins generated in the body, such as metabolic waste, can be removed through metabolism and renal clearance. If not properly removed, these metabolic wastes will accumulate in the body and become toxic. Although hemodialysis or peritoneal dialysis is currently used to reduce the content of metabolic waste in the blood, the current effect is still relatively limited, especially for some metabolic waste and toxins that are difficult to remove through osmotic pressure balance osmosis. Accordingly, there remains a need in the art for more effective compositions and methods capable of reducing toxins in the body. Contents of the invention [0004] In one aspect, the application provides a composition comprising an osmotic agent and a toxin-...

Claims

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Application Information

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IPC IPC(8): A61K31/79A61K33/00A61K31/718A61K31/7016A61K33/08A61K33/44A61P7/08A61P39/02B01J20/26B01J20/28B01J20/30A61M1/16A61M1/28
CPCA61K31/79A61K33/00A61K31/718A61K31/7016A61K33/08A61K33/44A61P7/08A61P39/02B01J20/26B01J20/267B01J20/103B01J20/14B01J20/264B01J20/08B01J20/20B01J20/28059B01J20/28061B01J20/28064B01J20/28078B01J20/28088B01J20/28054A61M1/1654A61M1/287A61K2300/00B01D61/005A61K45/06B01J20/2808B01J20/28083B01J20/28085
Inventor 蒋晨孙涛
Owner BEACON MEDCARE HK LTD
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