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Application of abietane derivatives in preparation of drugs for prevention and treatment of cerebral ischemic diseases

A technology for cerebral ischemic diseases and derivatives, applied in cardiovascular system diseases, nervous system diseases, pharmaceutical formulations, etc., can solve problems that have not been reported

Active Publication Date: 2019-11-01
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the published invention patents related to abietane derivatives can only see the preparation method, including Chinese patent applications CN106916162A, CN103819484A, CN104672251A, CN102850374A, and Chinese patent application CN108272807A discloses the application of petrosinolactone A in the preparation of anti-osteoporosis drugs , Chinese patent application CN107998124A discloses the application of petrosinolide B derivatives in the treatment of chronic obstructive pulmonary disease drugs, and Chinese patent application CN103860546A discloses the application of abietane derivatives in the treatment of anti-tuberculosis drugs, but has not been seen in Any report against cerebral ischemia-related diseases

Method used

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  • Application of abietane derivatives in preparation of drugs for prevention and treatment of cerebral ischemic diseases
  • Application of abietane derivatives in preparation of drugs for prevention and treatment of cerebral ischemic diseases
  • Application of abietane derivatives in preparation of drugs for prevention and treatment of cerebral ischemic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Tablets with rock euphoride B as the raw material medicine.

[0074] Each 1000 tablets contains the following ingredients:

[0075] Petropholide B 15g, hydroxypropyl methylcellulose 30g, talc powder 0.4g, lactose 0.2g, magnesium stearate 0.2g, absolute ethanol amount, made into 1000 tablets.

[0076] When preparing the above-mentioned tablet, take petogenolide B and mix evenly with hydroxypropyl methylcellulose, talcum powder, lactose, and magnesium stearate, add absolute ethanol to make soft material, pass through 24 mesh sieves, and prepare Form into granules, dry, add magnesium stearate, mix well, and compress into tablets.

Embodiment 2

[0078] Except that hydroxypropyl methylcellulose is 45g, all the other are with embodiment 1.

Embodiment 3

[0080] Except that the hydroxypropyl methylcellulose is 75g, all the other are with embodiment 1.

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Abstract

The invention relates to application of abietane derivatives in the preparation of drugs for the prevention and treatment of cerebral ischemic diseases, and particularly relates to the use of the abietane derivatives in the preparation of the drugs for prevention and treatment of nerve cell injury related diseases including the cerebral ischemic diseases, a cerebral ischemia-reperfusion injury, sequelae of cerebral ischemia, an oxidative stress-induced brain injury and the like. In the evaluation of drug activity, inventors found that the kind of the abietane derivatives has a significant protective effect on an ischemic brain injury, and can be used in clinical application as drugs for neurocyte injury related diseases such as cerebral ischemia.

Description

technical field [0001] The invention relates to the use of abietane derivatives, in particular to the application of a class of abietane derivatives in the pharmaceutical field. Background technique [0002] Abietane compounds are a class of natural organic compounds, mainly derived from Euphorbia plants of the Euphorbiaceae family, and are the main active ingredients of Euphorbia fischeriana. Their general structural formula is as follows: [0003] [0004] Jolkinolide is a diterpenoid isolated from the root of Euphorbia chamaejasma (E. fischeriana). Jolkinolide B (Jolkinolide B) is an abietane-type diterpenoid contained in the root of the Euphorbiaceae Euphorbiaceae (E. fischeriana). Jolkinolide B induces the expression of Caspase-3 protein in MDA-MB-231 breast cancer cells through mitochondrial release of cytochrome C, which has therapeutic applications in cancer (Oncol Rep.2012,27:1976-1980.). 17-Hydroxy-Jolkinolide B can strongly inhibit the combinatorial activatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K45/06A61P9/10A61P25/00
CPCA61K31/585A61K45/06A61P9/10A61P25/00A61K2300/00
Inventor 续洁琨张维库贺晓丽赫军张暖
Owner BEIJING UNIV OF CHINESE MEDICINE
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