Ror1-positive mesenchymal stem cell-containing pharmaceutical composition for preventing or treating disease associated with fibrosis, method for preparing same, and method for preventing or treating disease associated with fibrosis using ror1-positive mesenchymal stem cells

A technology of mesenchymal stem cells and treatment methods, applied in the direction of medical preparations containing active ingredients, drug combinations, biochemical equipment and methods, etc., can solve the problem that the therapeutic effect of mesenchymal stem cells cannot be said to be sufficient
CN110418645AInactive Publication Date: 2019-11-05ROHTO PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ROHTO PHARM CO LTD
Publication Date
2019-11-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The purpose of the present invention is to provide the following: novel mesenchymal stem cells having an excellent therapeutic effect on various diseases, particularly diseases associated with fibrosis; and a pharmaceutical composition containing such mesenchymal stem cells. The present invention is a therapeutic agent for fibrosis that contains ROR1-positive mesenchymal stem cells and / or a culture supernatant thereof and that is for preventing or treating a disease associated with fibrosis. The mesenchymal stem cells are CD29-, CD73-, CD90-, CD105-, and CD166-positive and are preferably derived from the umbilical cord or fat. In addition, the abovementioned disease associated with fibrosis is preferably a liver disease, a lung disease, a kidney disease, or a heart disease.
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Description

technical field

[0001] The present invention relates to a pharmaceutical composition for preventing or treating diseases accompanied by fibrosis containing ROR1-positive mesenchymal stem cells, a preparation method thereof, and prevention of diseases accompanied by fibrosis using ROR1-positive mesenchymal stem cells or disposal method. Background technique

[0002] In recent years, drug development and regenerative medical research using cells or tissues of living organisms are advancing and attracting attention. Among them, ES cells and iPS cells are being rapidly researched as organ regeneration technology or drug discovery and screening tools. On the other hand, cell therapy that isolates and uses somatic stem cells (mesenchymal stem cells) from bone marrow, adipose tissue, umbilical cord, etc., uses adult stem cells in regenerative medicine to repair tissues damaged by diseases, etc. Since it is inherently functional, it has attracted attention and been researched as a...

Claims

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