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A kind of isosorbide mononitrate slow-release tablet and preparation method

A technology of isosorbide dinitrate and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, drug combinations, etc.

Active Publication Date: 2022-01-28
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many bottlenecks in the research and development of 120mg isosorbide mononitrate sustained-release tablets, so it is necessary to provide a preparation method for 120mg isosorbide mononitrate sustained-release tablets

Method used

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  • A kind of isosorbide mononitrate slow-release tablet and preparation method
  • A kind of isosorbide mononitrate slow-release tablet and preparation method
  • A kind of isosorbide mononitrate slow-release tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Prescription

[0038]

[0039] 2) Preparation process:

[0040] (1) Accurately weigh the prescribed amount of isosorbide mononitrate and colloidal silicon dioxide and mix them for 10 minutes, pass through a 20-mesh sieve; (2) add the prescribed amount of hypromellose K200M and hydrogenated castor oil to the mixed powder and mix After 15 minutes, pass through a 20-mesh sieve; (3) add the prescribed amount of lactose and microcrystalline cellulose, mix for 15 minutes, and then pass through a 20-mesh sieve; (4) add the prescribed amount of talcum powder, mix for 5 minutes, and press into tablets.

Embodiment 2

[0042] 1) Prescription

[0043]

[0044] 2) Preparation process: the preparation process is the same as in Example 1.

Embodiment 3

[0046] 1) Prescription

[0047]

[0048] 2) Preparation process: the preparation process is the same as in Example 1.

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PUM

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Abstract

The invention belongs to the technical field of western medicine preparations, and specifically provides an isosorbide mononitrate sustained-release tablet and a preparation method thereof. The prescription of the sustained-release tablet of the present application consists of: isosorbide mononitrate, lactose, sustained-release materials, microcrystalline Cellulose, glidants and lubricants. The isosorbide mononitrate mixed powder prepared by the formula through a special preparation process has good fluidity and is suitable for direct powder compression, and the prepared sustained-release tablet has good stability and better sustained-release effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an isosorbide mononitrate sustained-release tablet and a preparation method thereof. Background technique [0002] Isosorbide mononitrate is a new generation of nitrate antianginal drugs, first developed by BoehringerMannheim GmbH.h in Germany. It is the main active metabolite of isosorbide dinitrate in vivo. It is absorbed quickly after oral administration, with high absolute bioavailability and small individual differences. Its biological half-life is 4-5 hours. Ordinary preparations need to be taken 2-3 times a day, and drug resistance is likely to develop after a few weeks of oral administration. Sustained-release preparations can effectively overcome drug resistance, and now isosorbide mononitrate sustained-release tablets have been widely used in clinical practice. [0003] Studies have found that the crystal form of isosorbide mononitrate i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/34A61K47/38A61K47/44A61P9/10
CPCA61K9/2054A61K9/2013A61K31/34A61P9/10
Inventor 张贵民贾俊伟冯中
Owner LUNAN PHARMA GROUP CORPORATION
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