Deep brain targeted electrical stimulation system based on multi-channel independent current sink

Abstract

The invention discloses a deep brain targeted electrical stimulation system based on a multi-channel independent current sink. The deep brain targeted electrical stimulation system comprises a logic control unit, a power management unit, a multi-channel voltage source circuit, a multi-channel current source circuit, a multi-channel current sink circuit, a charge balance circuit, an electrode configuration circuit, a blocking circuit and a feedback circuit. Through a plurality of independent current sink channels, different stimulation currents can be asynchronously output, stimulation currentswith the different amplitudes can also be output synchronously, the currents are applied to nucleus masses such as a GPi on the inner side part of a deep brain globus pallidum or a thalamus ventral intermediate nucleus VIM or a subthalamic nucleus STN, electrical activity of abnormal nerves in brain nucleus mass areas is regulated and controlled, tremor of the limbs and the trunk, myotonia and dyskinesia are controlled. According to the deep brain targeted electrical stimulation system based on the multi-channel independent current sink, the electrical stimulation side effect on other surrounding functional nucleus masses is greatly lowered, the negative half cycle is stimulated by a negative controllable voltage source or a current source for charge cancellation, the complete electricalneutrality of stimulus waveforms in the positive and negative directions is achieved, direct current accumulating is avoided, and biological tissue safety is protected.

Description

technical field [0001] The invention belongs to the field of nerve stimulation and relates to a deep brain targeted electrical stimulation system based on multi-channel independent current sinks. Background technique [0002] In 1997, the US FDA approved deep brain stimulation (DBS) for the treatment of essential tremor and Parkinson's disease (PD, Parkinson's disease); in 1998, China successfully carried out the first case of DBS surgery; in 2002, the US FDA approved DBS is used to control and alleviate the motor symptoms of Parkinson's disease in the middle and late stages; in 2012, epilepsy was successively approved as an indication for DBS treatment in Europe, Australia, South Korea and other countries. [0003] In recent years, there has been significant progress in the understanding of the pathogenesis of Parkinson's disease, the discovery of early diagnostic biomarkers, and the exploration of its treatment methods and means, and the treatment methods have become more ...

AI Technical Summary

Problems solved by technology

The reason for these side effects of stimulation is largely due to the fact that the internal stimulation source of the traditional DBS stimulator is single and the stimulation source pathways are few. Conventional DBS stimulation regulation uses a single fixed frequency and intensity to apply electrical pulses to the target nuclei. There will be a certain range of charge transfer effects around the point nuclei, which will cause the surrounding non-target nuclei to be electrically stimulated and cause some adverse reactions. The stimulation effects are as follows: Figure 9 There are also some new stimulation algorithms, which are based on high-frequency switching stimulation signals to apply electrical pulses at different electrode contacts, see Figure 5 It is shown that the high-frequency switching stimulation is generated alternately through the gaps of T0, T1, and T2, so that the charge is relatively concentrated in the affected area around the nuclei, and the stimulation effect is as follows: Figure 10 However, this algorithm is only an approximation to a certain extent, and does not directly act on the electrode contacts near the target in real time, so it can only appropriately reduce the side effects of stimulation on the surrounding non-target nuclei

Images