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Application of FCRL2 autoantibody detection reagent in preparation of lung cancer screening kit

An autoantibody and kit technology, applied in measurement devices, instruments, scientific instruments, etc., can solve unseen problems and achieve the effects of low patient harm, effective screening, and good application prospects

Active Publication Date: 2019-12-20
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it has been reported that FCRL2 protein can be used as a diagnostic marker for chronic lymphocytic leukemia; however, there are no related reports on FCRL2 protein autoantibodies, and there is no prior art related to FCRL2 protein autoantibodies and lung cancer

Method used

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  • Application of FCRL2 autoantibody detection reagent in preparation of lung cancer screening kit
  • Application of FCRL2 autoantibody detection reagent in preparation of lung cancer screening kit
  • Application of FCRL2 autoantibody detection reagent in preparation of lung cancer screening kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Relationship between FCRL2 autoantibodies in plasma and lung cancer

[0027] 1. Clinical data

[0028] 59 lung cancer patients and 30 healthy controls were selected. The basic information is as follows:

[0029] Basic Information lung cancer patients healthy control number of people 59 30 age 54.5±7.6 42±8.9 male ratio 37(62.7％) 13(46.7％)

[0030] 2. Detection principle

[0031] HuProt TM FCRL2 protein (full-length protein, Uniprot number: Q96LA5-2) is immobilized on the human protein custom chip. After incubation with serum, FCRL2 autoantibodies (mainly including IgG, IgM antibodies, and some other types of antibodies) in the serum will Bind to it, wash to remove unbound antibodies and other proteins, and then use anti-human IgM fluorescently labeled secondary antibody (cy5-labeled, red) and anti-human IgG fluorescent secondary antibody (cy3-labeled, green) to detect, and read through a fluorescent scanner The streng...

Embodiment 2

[0047] Embodiment 2 The composition of detection kit of the present invention and its using method

[0048] 1. Kit composition

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Abstract

The invention relates to the field of in-vitro diagnostic reagents, in particular to application of an FCRL2 autoantibody detection reagent in preparation of a lung cancer screening kit. According tothe invention, it is the first time to discover that the autoantibody level of FCRL2 protein in the serum of a lung cancer patient is obviously higher than the autoantibody level of FCRL2 protein in the serum of a healthy patient. Through adoption of the application of the invention, the reagent for detecting the FCRL2 protein autoantibody is used for preparing the lung cancer screening kit, so that effective screening of the lung cancer can be realized.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of FCRL2 autoantibody detection reagents in the preparation of lung cancer screening kits. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world. Its morbidity and mortality are increasing year by year. Currently, the incidence rate ranks first in the world, which seriously threatens human health and life. [0003] Lung cancer is a disease that is good at concealment. It often shows clinical symptoms when the disease develops to an advanced stage. 70-80% of lung cancer patients are already in the middle or late stage when they are diagnosed with lung cancer symptoms. The best cure time, five-year survival rate is low. For patients with early lung cancer, timely treatment can greatly improve the 5-year survival rate and quality of life of the patients. Therefore, early diagnosis and effective screening of lung cancer...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57423
Inventor 何彦琪张立李为民
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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