Application of miR-21 in diagnosis and treatment of subarachnoid hemorrhage

A subarachnoid, mir-21 technology, used in medical preparations containing active ingredients, blood diseases, gene therapy, etc. not clear, etc.
CN110684835APending Publication Date: 2020-01-14SHANDONG UNIV QILU HOSPITAL
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
SHANDONG UNIV QILU HOSPITAL
Publication Date
2020-01-14

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Abstract

The invention provides the application of miR-21 in the diagnosis and treatment of subarachnoid hemorrhage, and belongs to the technical field of biomedicine and molecular biology. According to the application of miR-21 in the diagnosis and treatment of subarachnoid hemorrhage, the potential therapeutic effects of mesenchymal stem cell exosomes in SAH are explored, particularly in the effect on cognitive function. It is proved that the mesenchymal stem cell exosomes can reduce early brain damage after SAH and improve the cognitive function. In the mechanism, it is demonstrated by the exosomesrich in miR-21 play an important role in mediating effect on inhibiting neuronal apoptosis. According to the application of miR-21 in the diagnosis and treatment of subarachnoid hemorrhage, it is actually proved that miR-21 in the mesenchymal stem cell exosomes reduces brain damage after SAH by inhibiting the neuronal apoptosis, the neural behavior is improved through a PTEN / Akt pathway, potentialnovel restorative treatment methods and strategies are provided for SAH patients with the risk of cognitive deficits, and thus the good practical application value is obtained.
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Description

technical field

[0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of miR-21 in the diagnosis and treatment of subarachnoid hemorrhage. Background technique

[0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art.

[0003] Subarachnoid hemorrhage (SAH) is a life-threatening neurological disease with high mortality and disability. With the advancement of neurosurgery diagnosis and treatment technology, many patients can survive, but it is completely difficult to restore normal cognitive function, and suffer from cognitive impairment, which reduces their quality of life. Accumulating evidence shows that early brain...

Claims

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