Application of neuronal guidance factor Sema in preparation of liniment for treating osteoarthritis
A technology of guiding factor and osteoarthritis, applied in the preparation of liniment for treating osteoarthritis, and the field of Sema macromolecular protein of nerve guiding factor, can solve the problems such as the application of Sema macromolecular protein liniment that has not been disclosed, and achieve prevention and slowing down of osteoarthritis Progression of inflammation, good compliance, and convenient use
Active Publication Date: 2020-01-21
WEST CHINA HOSPITAL SICHUAN UNIV
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- Abstract
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Problems solved by technology
Therefore, the pharmaceutical preparation of the present invention is different from the disease types used in the existing preparations, and the prior art has never disclosed the application of the liniment prepared by the Sema macromolecular protein as an active ingredient in the treatment of bone and joints.
Method used
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Embodiment 1
[0051] The preparation of embodiment 1 liniment
[0052] Dissolve 100 μg of Sema 3a human recombinant protein in 2 mL of ethanol, vortex and mix well to obtain a liniment with a drug concentration of 50 μg / mL.
Embodiment 2
[0053] The preparation of embodiment 2 liniments
[0054] Dissolve 100 μg of Sema 3a human recombinant protein in 2 mL of polyethylene glycol-400, vortex and mix well to obtain a liniment with a drug concentration of 50 μg / mL.
Embodiment 3
[0055] The preparation of embodiment 3 liniments
[0056] Dissolve 100 μg of Sema 3a human recombinant protein in 2 mL of polyethylene glycol-600, vortex and mix well to obtain a liniment with a drug concentration of 50 μg / mL.
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Abstract
The invention discloses application of a neuronal guidance factor Sema in preparation of a liniment for treating osteoarthritis. The neuronal guidance factor Sema is selected from Sema 3a proteins; and the Sema 3a proteins can be selected from natural proteins or recombinant proteins. Furthermore, the invention discloses a liniment based on the neuronal guidance factor Sema and a preparation method thereof. The liniment based on the neuronal guidance factor Sema comprises the following components: the neuronal guidance factor Sema, and a solvent; and concentration of the neuronal guidance factor Sema in the solvent is 50-100 microgramms / mL.
Description
technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the use of a nerve guiding factor Sema macromolecular protein in preparing a liniment for treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) refers to a synovial joint disease characterized by cartilage loss and periarticular bone reaction, also known as osteoarthritis, degenerative osteoarthritis, hypertrophic or hypertrophic arthritis, etc. Most common rheumatic disease worldwide. Osteoarthritis is the degenerative injury of articular cartilage, reactive hyperplasia of joint margins and subchondral bone caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and many other factors. Osteoarthritis is the most common joint disease among middle-aged and elderly people. According to survey research, the prevalence rate of people over 60 years old can reach 50%, and that of people over 75 years old can reach 80%....
Claims
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IPC IPC(8): A61K38/19A61P19/02A61P19/08
CPCA61K38/19A61K9/0014A61P19/02A61P19/08Y02A50/30
Inventor 黄石书王立平杨帆吴迪伟尤炫合高大双
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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