Detection method of N,N'-dicyclohexylurea and N,N'-dicyclohexylcarbodiimide

Abstract

The invention belongs to the field of chemical detection, and discloses a detection method of N,N'-dicyclohexylurea and N,N'-dicyclohexylcarbodiimide. The detection method comprises the following steps: dissolving a sample with methanol; diluting with acetone; filtering with an organic filter membrane; and detecting with a gas chromatograph-mass spectrometer. The method has the advantages of highseparation degree, symmetrical peak pattern and relatively higher accuracy and precision, and fills up the technical blank of the simultaneous qualitative and quantitative detection of the N,N'-dicyclohexylurea and the N,N'-dicyclohexylcarbodiimide.

Description

technical field [0001] The invention belongs to the field of chemical product detection, and relates to a detection method for N, N'-dicyclohexylurea and N, N'-dicyclohexylcarbodiimide, in particular to a gas chromatography-mass spectrometer for detection of N, Methods of N'-dicyclohexylurea and N,N'-dicyclohexylcarbodiimide. Background technique [0002] N,N'-Dicyclohexylcarbodiimide is a good low-temperature biochemical dehydrating agent, which is often used in the synthesis and dehydration of amikacin and amino acids, and also in the synthesis of acids, anhydrides, aldehydes, and ketones. When N,N'-dicyclohexylcarbodiimide is used as a dehydration condensation agent, it can react at room temperature for a short time to produce N,N'-dicyclohexylurea. Therefore, when N,N'-dicyclohexylcarbodiimide is added as a dehydrating agent, it is easy to introduce both N,N'-dicyclohexylurea and N,N'-dicyclohexylcarbodiimide into the product. kind of substance. [0003] The content o...

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Problems solved by technology

However, at present, the research on the qualitative and quantitative detection technology of N, N'-dicyclohexylurea and N, N'-dicyclohexylcarbodiimide at home and abroad is still blank.

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