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Hla-g transcripts and isoforms and their uses

A technology of HLA-G and transcripts, applied in anti-animal/human immunoglobulin, biomaterial analysis, recombinant DNA technology, etc.

Pending Publication Date: 2020-02-14
COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, according to the Ensembl database, the HLA-G gene may have an additional exon at the 5' end that is not present in the IMGT / HLA database
Also, since exon 7 corresponds to an untranslated domain, the question of whether it makes sense to treat it as an exon itself remains open

Method used

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  • Hla-g transcripts and isoforms and their uses
  • Hla-g transcripts and isoforms and their uses
  • Hla-g transcripts and isoforms and their uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0129] a. Detection and Analysis of Novel HLA-G Isotypes

[0130] 1. Materials and Methods

[0131] 1.1. Tumors and patients

[0132] All patients in this study underwent radical nephrectomy for ccRCC as the first therapeutic intervention between November 2014 and April 2015 at the Department of Urology at Saint-Louis Hospital (Paris, France). Median tumor size was 50 mm (range 35 to 175). According to the 2010 TNM classification of primary tumors, these tumors were classified as pT1a (patient 6), pT1b (patients 1, 3, and 8), and pT3a (patients 2, 4, 5, and 7). Two patients (patients 2 and 4) developed visceral metastases. Experienced uropathologists classified all these renal tumors as ccRCC according to the World Health Organization classification of renal tumors [8]. All patients participating in this study gave free and informed written consent. The study was approved by the Institutional Review Board of the Paris Saint-Louis Hospital.

[0133] 1.2. Tumor sample pr...

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Abstract

The invention pertains to the field of HLA-G molecules and their therapeutic use. The invention pertains to new HLA-G isoforms, that is to say new RNA transcripts and proteins deriving from the HLA-Ggene, pharmaceutical composition comprising thereof, as well as primers specific of these transcripts and antibodies specific of these proteins. The invention further pertains to the diagnostic or therapeutic use of these molecules.

Description

technical field [0001] The present invention relates to the field of HLA-G molecules and their therapeutic use. The present invention relates to novel HLA-G isoforms, namely novel RNA transcripts and proteins derived from the HLA-G gene, pharmaceutical compositions comprising them, as well as specific primers for these transcripts and specific antibodies for these proteins . The invention further relates to the diagnostic or therapeutic use of these molecules. Background technique [0002] HLA-G is an HLA class Ib molecule with potent immunomodulatory activity that is expressed under physiological conditions that require modulation of the immune response to avoid allograft recognition (ie, the maternal-fetal interface or in transplant patients). HLA-G was first described to play a key role in the maintenance of pregnancy [1] and was found to be constitutively expressed at the fetomaternal interface in extravillous cytotrophoblast cells. [0003] HLA-G has a tolerogenic ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/74C07K16/28
CPCC07K14/70539G01N2333/70539C07K16/2833C07K2317/33C12N15/79C07K14/47A61K38/1709A61K38/1774
Inventor E·D·卡罗塞拉戴安娜·特罗尼克-勒·鲁简-菲利普·戴斯里斯杰罗姆·韦瑞尼弗朗索瓦·帝格朗尚N·鲁阿-弗雷斯乔尔·勒马约特
Owner COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
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