Contrast medium for microangiography

A contrast agent and microvascular technology, which can be used in the preparation of X-ray contrast agents, preparations for in vivo experiments, and pharmaceutical formulations, and can solve problems such as high viscosity perfusion.

Pending Publication Date: 2020-02-21
PITENGO GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to published studies, perfusion may still be insufficient due to relatively high viscosity (Perrien, D.S. 2016)

Method used

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  • Contrast medium for microangiography
  • Contrast medium for microangiography
  • Contrast medium for microangiography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0064] 1. Preparation of each component:

[0065] Supplied in 3 containers. Container 1 is filled with iodinated esterified oil, preferably iodinated esterified linseed oil and 2-butanone (C 4 h 8 O) and a first mixture of dye (BlueDye from VasQtec). In the context of this application, this first mixture is referred to as "contrast solution", with or without dye. Container 2 is filled with polyurethane (PU). Container 3 contains curing agent.

[0066] 2. Remove contrast solution from container 1:

[0067] A 12 ml disposable syringe (e.g. Monoject syringe with luer lock c1086, Qosina) screwed onto the Luer connector of container 1 (Needlefree Swabably Valve Female Luer to 20mm Vial Cap Polycarbonate, Value Plastic); inject 5 ml of air into the container 1 (upright pressure), rotate container 1 to draw all the contrast solution into the syringe.

[0068] 3. Prepare a second mixture of contrast solution and polyurethane:

[0069] Inject contrast solution into container 2 ...

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Abstract

The invention relates to a contrast medium for ex vivo microangiography for digital imaging of the vascular system of a mouse or rat or other laboratory animals, and of individual animal and human organs, comprising an iodized, esterified oil, a polyurethane, and a hardener. The invention further relates to a method for producing the contrast medium; to a kit of parts, comprising the various containers having the components of the contrast medium according to the invention that are to be mixed; and to a preferred use of the contrast medium according to the invention for imaging by means of a micro-CT device.

Description

technical field [0001] The present invention relates to contrast agents for post-mortem microangiography, i.e. for imaging the vascular system, especially for small animals (e.g. mice, rats) by means of X-ray based imaging methods, especially nano or Micro-CT devices. or other experimental animals), as well as the vasculature of individual animal organs and human organs for digital imaging. Background technique [0002] The purpose of microangiography is to three-dimensionally visualize the smallest blood vessels, ie capillaries of a single organ or throughout the body and reproduce them precisely for analysis. However, especially for pharmacological research, as well as in forensic science, the analysis of intact blood vessels is necessary. To date, basically two techniques have been used to map microvessels: the so-called cast method, and radiocontrast mapping, in particular method. [0003] In the past few years, 3D rendering methods such as micro-computed tomography ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K49/04
CPCA61K49/0438A61K49/0447A61K49/0452A61K2123/00
Inventor 比特·施特格鲁斯兰·赫卢修克瓦伦丁·乔诺维
Owner PITENGO GMBH
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