Specific modified electrode based on metal organic framework and preparation and application thereof

A metal-organic framework, metal-organic framework technology, applied in the direction of electrochemical variables of materials, material analysis by electromagnetic means, instruments, etc., can solve problems such as limiting the application of sensors

Active Publication Date: 2020-03-06
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, graphene oxide is prone to agglomeration in water due to van der Waals interaction and π-π stacking, which limits their further applications in sensors.

Method used

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  • Specific modified electrode based on metal organic framework and preparation and application thereof
  • Specific modified electrode based on metal organic framework and preparation and application thereof
  • Specific modified electrode based on metal organic framework and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1, Au / NH 2 -Cu 3 (btc) 2 - Construction of rGO / GCE

[0044] (1) NH 2 -Cu 3 (btc) 2 Preparation: Take 1.22g of copper nitrate and add it to 8.5mL of ionized water; take 0.58g of trimesic acid and 0.18g of 2-aminoterephthalic acid, add it to 17mL of a mixture of N,N-dimethylformamide and ethanol Medium (8.5mL each). Stir under magnetic force for 0.5h; transfer the solution to a steel autoclave lined with polytetrafluoroethylene, keep the reaction temperature at 85°C for 24h, cool to room temperature, filter, and wash with N,N-dimethylformaldehyde Amide and ethanol washed, dried in vacuo at 60 °C to give NH 2 -Cu 3 (btc) 2 ;

[0045] (2) Preparation of rGO: Add 300 mg GO to 100 mL H 2 In a round-bottomed flask of O, ultrasonically disperse for 2 h, put 3 mLN 2 h 4 Added to the suspension, and the suspension was stirred at 95°C for 24h, cooled to room temperature, filtered and washed with deionized water and ethanol respectively, and the product was vac...

Embodiment 2

[0048] Example 2, Au / NH 2 -Cu 3 (btc) 2 - rGO / GCE electrochemical sensor for simultaneous detection of acetaminophen and p-aminophen

[0049](1) Preparation of sample solution: Weigh 37.8 mg of paracetamol and 27.3 mg of paracetamol respectively, and adjust the volume to 25 mL with a phosphate buffer solution with a pH of 8, that is, the prepared concentration is 1×10 -2 Mother liquor of M. Pipette 0.25 mL of the mother liquor for dilution to prepare a sample solution with a paracetamol concentration of 100 μM and a paraaminophen concentration of 100 μM;

[0050] (2) Detection of acetaminophen and p-aminophenol: Au / NH prepared in Example 1 2 -Cu 3 (btc) 2 - rGO / GCE modified electrode, platinum electrode and saturated calomel electrode are three-electrode system, put in phosphate buffer solution (pH=8) containing acetaminophen and p-aminophenol, and scan by differential pulse voltammetry , the scanning potential range is -0.3~0.7V;

[0051] (3) Test results: According t...

Embodiment 3

[0052] Example 3, Au / NH 2 -Cu 3 (btc) 2 - rGO / GCE electrochemical sensor for simultaneous detection of acetaminophen and p-aminophen

[0053] (1) Preparation of sample solution: Weigh 37.8 mg of paracetamol and 27.3 mg of paracetamol respectively, and adjust the volume to 25 mL with a phosphate buffer solution with a pH of 8, that is, the prepared concentration is 1×10 -2 Mother liquor of M. Pipette 0.5mL of the mother liquor for dilution to prepare a sample solution with acetaminophen concentration of 200 μM and para-aminophen concentration of 200 μM;

[0054] (2) Detection of acetaminophen and p-aminophenol: Au / NH prepared in Example 1 2 -Cu 3 (btc) 2 - rGO / GCE modified electrode, platinum electrode and saturated calomel electrode are three-electrode system, put in phosphate buffer solution (pH=8) containing acetaminophen and p-aminophenol, and scan by differential pulse voltammetry , the scanning potential range is -0.3~0.7V;

[0055] (3) Test results: According to ...

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Abstract

The invention provides a construction method of a specific modified electrode based on a metal organic framework. The preparation method comprises the steps of ultrasonically dispersing an aminated metal organic framework and reduced graphene oxide into N, N-dimethylformamide, and dropwise coating a dispersion liquid on the surface of a polished glassy carbon electrode to prepare a modified electrode rGO-NH2-Cu3(btc)2/GCE; forming a three-electrode system by taking the rGO-NH2-Cu3(btc)2/GCE modified electrode as a working electrode; putting the electrode into an H2SO4 solution containing HAuCl4; and depositing the gold nanoparticles on the surface of the electrode by adopting a potentiostatic deposition method, so as to prepare the specific modified electrode Au/rGO-NH2-Cu3(btc)2/GCE. Themodified electrode can completely separate oxidation peaks of acetaminophen and p-aminophenol, so that simultaneous detection of acetaminophen and p-aminophenol is realized. The detection method is rapid, simple and convenient, and has good anti-interference performance and stability.

Description

technical field [0001] The invention relates to a construction method of a metal-organic framework-based specific modification electrode, which is mainly used for the detection of acetaminophen and para-aminophenol, and belongs to the technical field of electrochemical sensors and electrochemical analysis. Background technique [0002] As an analgesic and cold medicine, paracetamol (ACOP) (N-acetyl-para-aminophenol or acetaminophen) is mainly used to relieve moderate pain related to fever, headache, arthritis, post-operative pain and back pain. However, accumulation of toxic metabolites of acetaminophen in excess can lead to serious and sometimes fatal hepatotoxicity, inflammation of the pancreas and skin. 4-Aminophenol (4-AP) is the main hydrolytic degradation product of ACOP. As a synthetic intermediate or degradation product of ACOP, 4-AP has obvious nephrotoxicity and teratogenic effects. Therefore, developing a simple, sensitive and accurate method to detect ACOP and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 郭昊姚文琴刘慧杨武
Owner NORTHWEST NORMAL UNIVERSITY
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