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Complex, tissue repair material, preparation method of the tissue repair material and applications

A tissue repair and complex technology, applied in unknown raw materials, drug combinations, pharmaceutical formulations, etc., can solve the problems of limited human tolerance, cumbersome synthesis process, and immune response, and achieve the ability to promote tissue repair, high purity, Healing effect

Active Publication Date: 2020-03-27
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although artificially synthesized liposomes are convenient for modifying functional groups, the cost is greatly increased, and the synthesis process is more cumbersome, and liposomes are derived from foreign substances, the human body has limited tolerance, and it is easy to generate immune reactions in the body

Method used

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  • Complex, tissue repair material, preparation method of the tissue repair material and applications
  • Complex, tissue repair material, preparation method of the tissue repair material and applications
  • Complex, tissue repair material, preparation method of the tissue repair material and applications

Examples

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Effect test

Embodiment 1

[0173] An embodiment of the present invention provides a complex, the complex is formed by combining a targeting group and a medicinal vesicle, the targeting group is selected from aptamers, and the medicinal vesicle is selected from exocrine body.

[0174] The embodiment of the present invention utilizes the targeting effect of aptamers on specific cells to make exosomes migrate and act on target cells, thereby improving the bioavailability of exosomes and achieving the purpose of promoting tissue repair. Aptamer-modified exosomes can accelerate the growth and migration of fibroblasts from chronic non-healing wounds, and can effectively activate growth factor signaling pathways, increase the expression of angiogenesis-related genes and matrix proteins, and induce neovascularization Therefore, the complex provided by the invention can be used as a safe and effective product to promote the healing of chronic difficult-to-heal wounds or bone defect wounds.

[0175] In some embo...

Embodiment 2

[0212] This embodiment provides a composition, the active ingredient of which is the complex described in Embodiment 1. The composition of the present invention can accelerate the growth and migration of fibroblasts from chronic non-healing wounds, and can effectively activate growth factor signaling pathways, increase the expression of angiogenesis-related genes and matrix proteins, and induce the formation of new blood vessels or osteoblasts Therefore, the composition provided by the invention can be used as a safe and effective product to promote the healing of chronic difficult-to-heal wounds or bone defect wounds.

Embodiment 3

[0214] This example provides the use of the complex in Example 1 or the composition in Example 2 in promoting angiogenesis. The blood vessels include arterial blood vessels, venous blood vessels and capillaries. The capillaries include capillaries present in the dermis of the skin, bone tissue, and cardiomyocytes.

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Abstract

The invention provides a complex, a tissue repair material, a preparation method of the tissue repair material and applications. The complex is stable in medicinal effect, high in targeting and high in transfer efficiency, and has good tolerance in vivo; and various biological functions can be achieved through endogenous matters, and immune response in vivo can be avoided. The tissue repair material has stable treatment effects and targeting on treating skin diseases, and especially has significant effects on treating diabetic complications which cannot be healed for a long time.

Description

technical field [0001] The invention belongs to the technical field of biological products, and in particular relates to a complex, a tissue repair material and a preparation method and application thereof. Background technique [0002] The damage or dysfunction of tissues and organs is one of the main hazards faced by human health, and it is also the most important cause of human disease and death. Currently, there are three common clinical repair techniques for tissue and organ defects: allogeneic tissue transplantation, but there are serious shortages of histocompatibility and donor sources; It often leads to dysfunction; the application of artificial synthetic material substitutes can easily lead to foreign body reactions, secondary infections, and atrophy of surrounding tissues. [0003] Mesenchymal stem cells are an important member of the stem cell family. They are derived from the mesoderm in the early stages of development. They have the characteristics of multi-di...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K47/54A61K47/60A61P3/10A61P17/02A61P19/08C08G65/333
CPCA61K35/28A61K47/549A61K47/60A61P17/02A61P19/08A61P3/10C08G65/33337C08G65/33306
Inventor 胡成虎赵娜
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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