Application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease
A technology for Alzheimer's disease and cycloastragenol, which is applied in the field of medicine to achieve good therapeutic effects, inhibit inflammation, and reduce deposition
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[0035] The present invention will be further described below in conjunction with specific embodiments, so that those skilled in the art can better understand the present invention, but the present invention is not limited thereby.
[0036] Pharmacological data of cycloastragalol in the treatment of Alzheimer's disease
[0037] Experiment 1: Evaluation of cycloastragalol on the phagocytic function of microglia
[0038] Experimental materials: BV-2 cells are murine microglia cell lines with the functions and basic characteristics of primary microglia. Use fetal bovine serum and high-sugar medium containing 0.25% pancreatin EDTA, penicillin and streptomycin medium. Nile red microglobulin, lyophilized powder Aβ1-42 and Hilyte555-Aβ1-42 were purchased from Anaspec. The CCK8 reagent for detecting cell viability was purchased from Hyclone.
[0039] experimental method:
[0040] 1-1 Use CCK8 reagent to detect the optimal concentration of cycloastragenol on BV2 cells. After intervention of B...
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