Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease

A technology for Alzheimer's disease and cycloastragenol, which is applied in the field of medicine to achieve good therapeutic effects, inhibit inflammation, and reduce deposition

Pending Publication Date: 2020-04-10
潘晓东
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cycloastragenol has not been used in the prevention or treatment of Alzheimer's disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease
  • Application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease
  • Application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] The present invention will be further described below in combination with specific embodiments, so that those skilled in the art can better understand the present invention, but the present invention is not limited thereby.

[0036] Pharmacological experimental data of cycloastragenol in the treatment of Alzheimer's disease

[0037] Experiment 1: Evaluation of cycloastragenol on the phagocytosis of microglia

[0038] Experimental materials: BV-2 cells are a mouse microglial cell line with the functions and basic characteristics of primary microglial cells. Fetal bovine serum and high glucose medium containing 0.25% trypsin EDTA, penicillin and streptomycin were used for cultivation. Nile red microglobulin, freeze-dried powder Aβ1-42 and Hilyte555-Aβ1-42 were purchased from Anaspec. The CCK8 reagent for detecting cell activity was purchased from Hyclone Company.

[0039] experimental method:

[0040] 1-1 The optimal concentration of cycloastragenol to BV2 cells was d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides an application of cycloastragenol in preparing medicines for treating or preventing Alzheimer's disease. Cycloastragenol can promote elimination of key pathological amyloid protein (Abeta) deposition in a brain suffered from Alzheimer's disease and inhibit inflammatory reactions of microglia cells, so that deposition of aging-related substances in the brain is obviously reduced, and aging is resisted. Cycloastragenol can improve glucose metabolism capacity in brain tissues, and has good protection and treatment effects on damage of learning and memory capabilities and behavioral movement capacity caused by Abeta deposition. The features make cycloastragalol suitable for being used in prevention and treatment of Alzheimer's disease, and a solution is providedfor long-troubled treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new medicinal application of cycloastragenol, in particular to the application of cycloastragenol in the preparation of drugs for treating Alzheimer's disease. Cycloastragenol can promote the removal of key pathological amyloid (Aβ) deposits in the brain of Alzheimer's disease, inhibit the inflammatory response of microglial cells, significantly reduce the deposition of aging-related substances in the brain, anti-aging, and improve brain tissue. The ability to metabolize glucose has good protective and therapeutic effects on learning, memory, and behavioral motor ability damage caused by Aβ deposition, so it can be used to prepare drugs for preventing or treating Alzheimer's disease. Background technique [0002] At present, the core hypothesis of Alzheimer's disease (AD), Aβ, has been developed, and the theory of abnormal immune inflammation has become the mainstream mechanism ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/58A61P25/28A61P37/02A61P3/08
CPCA61K31/58A61P25/28A61P37/02A61P3/08
Inventor 潘晓东张秋阳林宝平冯林娟
Owner 潘晓东
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com