Methods for treating cancer

A cancer, therapeutic agent technology, applied in the field of treating patients suffering from cancer, capable of solving major and other problems

Inactive Publication Date: 2020-04-10
X4 PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] These data underscore a significant unmet need to investigate CXCR4 inhibitors for the treatment of cell proliferative disorders due to overexpression or aberrant expression of CXCR4

Method used

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  • Methods for treating cancer
  • Methods for treating cancer
  • Methods for treating cancer

Examples

Experimental program
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Effect test

example 1

[0505] Example 1 - Measurement of CD8+ T cells

[0506] Assessment of the effectiveness of the present invention can be performed in part by measuring the CD8+ T cell population. Enlarging or increasing the density of tumor-infiltrating lymphocytes, especially CD8+ T cells, can help kill tumor cells. Dudley et al. (2010) Clin. Cancer Research, 16:6122-6131. Herr et al. (1996), J. Immunol. Methods, 191: 131-142; Herr et al. (1997), J. Immunol. Methods, can be used . Methods), 203: 141-152; and methods described in Scheibenbogen et al. (2000), J Immunol. Methods, 244: 81-89 to detect, isolate and quantify CD8 +T cells. The entire disclosures of each of these publications are incorporated herein by reference.

example 2

[0507] Example 2 - Renal Cell Carcinoma Xenograft Model

[0508] To assess the effect of the present invention on renal cell carcinoma, a human RCC xenograft model can be used, eg Pavia-Jimenez et al. (2014) Nature Protocols, 9:1848 -1859; described in Grisanzio et al. (2011), J Pathol, 225:212-221. The entire disclosures of each of these publications are incorporated herein by reference.

example 3

[0509] EXAMPLE 3 - CRITERIA FOR ASSESSING RESPONSE IN SOLID TUMOR PATIENTS

[0510] Response of patients with solid tumors to therapy can be assessed using the criteria set forth in RECIST 1.1 (Eisenhauer et al (2009), Eur. J. Cancer, 45:228-247), which The entire disclosure is incorporated herein by reference.

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Abstract

The present invention relates to methods of treating cancer, in which a CXCR4 inhibitor such as X4P-001 or a pharmaceutically acceptable salt thereof or pharmaceutical composition thereof is administered in combination with an additional therapeutic agent, such as an immune checkpoint inhibitor. The methods demonstrate surprising results, including regression of disease, with comparatively littletoxicity.

Description

technical field [0001] The present invention relates to methods for treating cancer, eg, methods for treating patients with cancer (eg, solid tumors). [0002] CROSS-REFERENCE TO RELATED APPLICATIONS [0003] This application claims the benefit of priority from US Provisional Patent Application Serial No. US 62 / 523,091, filed June 21, 2017, the entire contents of which are incorporated herein by reference. Background technique [0004] Cancer poses a persistent and significant threat to human health worldwide. It is increasingly clear that cancer is a collection of heterogeneous and multifaceted diseases with less in common than previously thought. The genetic and phenotypic heterogeneity of cancer is both a challenge and an opportunity. The challenge is that there doesn't seem to be a single treatment for all cancers. The opportunity, however, is that with each new discovery of new mechanisms for tumorigenesis, angiogenesis, metastasis, and other processes on which can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4709A61K39/395A61P35/00A61P37/04
CPCA61K45/06A61K31/454A61K31/4709A61K31/502A61K31/55A61P37/04A61P35/00A61K39/3955C07K16/2818A61K2039/505A61K31/519A61K2300/00A61K33/243A61K31/167A61K31/18A61K31/337A61K31/4025A61K31/404A61K31/405A61K31/4188A61K31/4245A61K31/4406A61K31/4439A61K31/4462A61K31/47A61K31/5025A61K31/506A61K31/52A61K31/53A61K31/553A61K38/05A61K38/15
Inventor S·帕拉素拉马Y·王
Owner X4 PHARMA INC
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