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Metabolite composition for pre-operative early warning of kidney delayed graft function of donor donated after cardiac death and screening method of compsition

A cardiac death and screening method technology, applied in the field of analysis, can solve the problems of differential analysis that have not been reported yet, and achieve the effect of reducing the probability of occurrence

Active Publication Date: 2020-04-24
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the analysis of delayed recovery events in kidney transplantation based on metabolomics technology comes from the postoperative samples of recipients, and the difference analysis of donors before surgery has not been reported.

Method used

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  • Metabolite composition for pre-operative early warning of kidney delayed graft function of donor donated after cardiac death and screening method of compsition
  • Metabolite composition for pre-operative early warning of kidney delayed graft function of donor donated after cardiac death and screening method of compsition
  • Metabolite composition for pre-operative early warning of kidney delayed graft function of donor donated after cardiac death and screening method of compsition

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Embodiment 1

[0032] DGF after renal transplantation is a common clinical adverse event, and the diagnostic criteria are low urine output within 1 week after operation and the need for transition to dialysis. Two kidneys from the same donor will have differences in functional recovery in different recipients. According to the postoperative renal function recovery of both recipients, DCD kidney transplant donors are grouped: both recipients have DGF The donor in the Double-DGF group, the donor in which the renal function of both recipients recovered and stabilized was in the None-DGF group, and blood samples were obtained from the above two groups.

[0033] Stable recovery of renal function was defined as postoperative serum creatinine was stable within 20% of the baseline value, and there were no postoperative complications such as acute rejection, lymphatic leakage, urinary fistula, perirenal hematoma, and polyoma virus infection. The diagnosis of acute rejection was made by the transplant...

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Abstract

The invention discloses a metabolic composition for pre-operative early warning of kidney delayed graft function of a donor donated after cardiac death. The metabolic composition is prepared from oneor more selected from seven metabolites including ascorbic acid, diaminopimelic acid, cinnamic acid, isobutyl-isobutyrate, androstenedione, 3-oxocaprylic acid and uroporphyrin. The invention further discloses a screening method of the metabolic composition. In the screened metabolic composition, the binding indication rate of ascorbic acid and diaminopimelic acid is 0.823, and the binding indication rate of cinnamic acid, isobutyl-isobutyrate, androstenedione, 3-oxocaprylic acid and uroporphyrin is 0.98.

Description

technical field [0001] The invention belongs to the field of analysis technology, and specifically relates to a metabolic composition and a screening method for early warning of delayed recovery of transplanted kidneys after cardiac death in donors. Background technique [0002] Delayed graft function (DGF) is a clinical phenomenon that fails to recover physiological function within one week after kidney transplantation and requires transition to dialysis, and is an independent risk factor affecting the survival of transplanted kidney [P.N.C.D.S.M. et al., Delayed graft function in kidney transplantation. Lancet, 2004. 364(9447)]. In recent years, with the popularization of donation after cardiac death (DCD), the incidence of DGF has increased significantly. On the one hand, the acquisition of DCD kidneys can only be carried out after the donor’s heart function stops, so the donor kidney will experience a longer warm ischemia time than the living donor kidney, and the chang...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/36G01N30/72G01N30/88G16C20/64G16C20/70
CPCG01N30/02G01N30/06G01N30/34G01N30/36G01N30/7266G01N30/88G01N2030/027G01N2030/8822G16C20/64G16C20/70
Inventor 沈佳邓皓陈德莹黄洪锋陈江华王仁定
Owner ZHEJIANG UNIV
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