32 results about "Diaminopimelic acid" patented technology

Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.

The present invention provides a method and composition for the treatment and prevention of an autoimmune disease such a multiple sclerosis which is mediated by autoreactive T cells. The administration of a NOD-1 agonist is shown to mediate an anti-inflammatory immune response. NOD-1 agonists suitable for use in the methods and compositions of the invention include diaminopimelic acid (DAP)-containing muropeptide compounds such as Tri-DAP and M-TriDAP.

The present invention relates to certain heterocyclic compounds of formula (1) that have the ability to inhibit lysine biosynthesis via the diaminopimelate biosynthesis pathway in certain organisms. As a result of this activity these compounds can be used in applications where inhibition of lysine biosynthesis is useful. Applications of this type include the use of the compounds as herbicides.

The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase, the DNA coding for diaminopimelate decarboxylase, and the DNA coding for diaminopimelate dehydrogenase.

The purpose of the present invention is to provide a novel method with which it is possible to quantify diaminopimelic acid-containing bacteria contained in a test sample. The present invention relates to a method for quantifying diaminopimelic acid-containing bacteria contained in a sample to be detected, the method being characterized by comprising: determining the amount of diaminopimelic acid derived from the diaminopimelic acid-containing bacteria in the sample to be detected as an index, and determining the amount of diaminopimelic acid derived from the diaminopimelic acid-containing bacteria in the sample to be detected; and a step for quantifying the bacteria containing diaminopimelic acid.

L-lysine is produced by culturing the following Escherichia coli having L-lysine-producing ability in a medium modified to reduce the endogenous One or more enzymes of the racemic α,ε-diaminopimelic acid synthesis pathway, such as 2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid N-succinyltransferase, The activity of succinyldiaminopimelate transaminase, succinyldiaminopimelate desuccinylase or diaminopimelate epimerase, and a gene encoding diaminopimelate dehydrogenase is introduced therein.

The invention provides a synthetic method of D-heterocyclic amino acid, a kit and an application. The synthetic method comprises the step that a keto acid compound of D-heterocycles is transformed into D-heterocyclic amino acid by diaminopimelic acid dehydrogenase shown as SEQ ID NO:1. The keto acid compound of D-heterocycles is transformed into D-heterocyclic amino acid by diaminopimelic acid dehydrogenase, so that non-natural chiral amino acid with higher transformation rate and higher ee can be obtained, the synthetic method based on diaminopimelic acid dehydrogenase adopts stable technological conditions and mild reaction conditions, the whole production process is simple to operate, less pollution is produced, and one new way of thinking is provided for artificial synthesis of D-heterocyclic amino acid.

The invention relates to an antibiotic streptomyces, fermentation product of which can inhibit broad spectrum fungus and protozoan, and field experiment can control crop fungus plant disease and root-knot nematode. The antibiotic streptomyces has good effect, no pollution nuisance and no residue. The antifungal agent has extremely low hazardness for the people and good performance and developmentprospect for medical and agricultural use. The invention is named as SIM001 antibiotic streptomyces which is Streptomyces antibioticus subspecies xi an, and is preserved as patent in the depositary institution appointed by patent office of state intellectual property office; the preservation data is April 14th, 2005, the name of the depositary institution is CGMCC, and the number of preservation is CGMCC No.1349. The whole cell hydrolysate of the antibiotic streptomyces contains L, L-DAP (Diaminopimelic acid) and no characteristic glucide; the cytoderm belongs to I type and glucide type C; one of the main antibacterial materials is polyene macrocyclic ketolide which belongs to the broad spectrum antifungal substance.

The invention is applicable to the technical field of plant cultivation, and provides an ornamental plant cultivation medium, a bottled ornamental plant and a preparation method of the bottled ornamental plant. A formula of the ornamental plant cultivation medium is as follows: a 1 / 2MS cultivation medium is used as a basic material, meanwhile 1.8-2.3 g / L of agar, 7-9 g / L of phytagel, 48-53 mg / L of diaminopimelic acid, 9.5-10.5 [mu]mol / L of PQQ and 23-26 mg / L of kanamycin are added, and then the pH value of the ornamental plant cultivation medium is adjusted to be 6.5-6.9. The provided cultivation medium can be used for accelerating plant growth, is also relatively firm, is suitable for long-time plant growth, and is particularly suitable for being used as the cultivation medium of the bottled ornamental plant; the plant is relatively vigorous in growth, relatively strong in stability, better in ornamental value and longer in growth cycle.

This invention relates to an isolated nucleic acid fragment encoding a plant enzyme that catalyze steps in the biosynthesis of lysine, threonine, methionine, cysteine and isoleucine from aspartate, the enzyme a member selected from the group consisting of: dihydrodipicolinate reductase, diaminopimelate epimerase, threonine synthase, threonine deaminase and S-adenosylmethionine synthetase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the enzyme in a transformed host cell.