Lipid-lowering compounds commiphorine A and application thereof in pharmacy

A compound and lipid technology, applied in organic chemistry, pharmaceutical formulation, drug combination, etc., can solve problems that have not been reported in the literature

Inactive Publication Date: 2020-05-15
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, we have conducted research on the lipid-lowering activity of the newly discovered commiphorine A, and found that commiphorine A can significantly inhibit the formation of lipids in HepG2 cells, suggesting that this sesquiterpene dimer compound has a certain effect on the treatment of lipid metabolism, while Related research has not been reported in the literature

Method used

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  • Lipid-lowering compounds commiphorine A and application thereof in pharmacy
  • Lipid-lowering compounds commiphorine A and application thereof in pharmacy
  • Lipid-lowering compounds commiphorine A and application thereof in pharmacy

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Extraction, separation and structural identification of the compound described in the present invention

[0022] The dry resin of myrrh (50kg) was pulverized and extracted by cold soaking with 95% ethanol for 3 times, 180L each time, 48 hours each time, the solvent was recovered and concentrated to obtain the extract (10kg). The extract was properly diluted with warm water and then extracted three times with ethyl acetate to obtain the ethyl acetate extraction fraction (8kg).

[0023] The ethyl acetate extraction part (8kg) was subjected to silica gel column chromatography (petroleum ether-acetone, 100:0,100:1,50:1, 20:1,10:1,5:1,3:1,1:1,0: 100) Separated to obtain 6 components (Fr.A~Fr.F). Fr.B (2.4kg) was subjected to silica gel column chromatography (petroleum ether-ethyl acetate, 100:0,100:1,60:1,40:1,20:1,5:1,3:1,1:1) and Petroleum ether-acetone (5:1, 3:1, 1:1) separated to obtain 6 components (Fr.B.1~Fr.B.6). Fr.B.3 (32.1g) was separated by MCI gel CHP 20P colu...

Embodiment 2

[0028] Any one of the compound commiphorines A in Example 1 can be made into an injection solution after adding injection solvent according to conventional methods, fine filtration, potting and sterilization.

Embodiment 3

[0030] Any one of the compound commiphorine A in Example 1 can be made into tablets according to conventional methods with various pharmaceutical adjuvants.

[0031] Use any one of the compound commiphorine A in Example 1 as the pharmaceutical active ingredient, use several excipients as the auxiliary material components for the preparation of the combination drug tablet, and make each tablet containing 1-100 mg of the pharmaceutical ingredient according to a certain ratio. Tablet samples.

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Abstract

The invention provides two new sesquiterpene dimer compounds capable of inhibiting the formation of lipids in HepG2 cells. The new sesquiterpene dimer compounds are named commiphorine A. The inventionalso provides a pharmaceutical composition containing the compounds and an extraction and separation method of the compounds. The compounds have the effect of inhibiting lipid formation in HepG2 cells, and prompt the value of the compounds in the aspect of treating lipid metabolism related diseases.

Description

Technical field: [0001] The invention belongs to the field of chemical medicine, and relates to a new compound commiphorine A and its application in treating lipid metabolism diseases. Background technique: [0002] Myrrha is a natural resin derived from the dried exudate of the plant Commiphora myrrha Engl. in the olive family (Burseraceae) or its congeners. It has a long history of medicinal use in our country. In recent years, myrrh has become a research focus of domestic and foreign scholars, especially the research reports on terpenoids. Since we first reported sesquiterpene dimer compounds with novel structures from myrrh in 2018, we have also discovered and reported such compounds one after another. etc. effect. At present, we have conducted research on the lipid-lowering activity of the newly discovered commiphorine A, and found that commiphorine A can significantly inhibit the formation of lipids in HepG2 cells, suggesting that this sesquiterpene dimer compound ha...

Claims

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Application Information

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IPC IPC(8): C07D493/10A61P3/06A61K31/343
CPCC07D493/10A61P3/06
Inventor程永现董璐秦大鹏刘颖
OwnerSHENZHEN UNIV