Use of UIMC1 gene as molecular marker for judging radiation injury susceptibility

A technology of molecular markers and radiation damage, which is applied in the determination/inspection of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problems of increasing the uncertainty of radiation carcinogenic risk, and achieve low cost and mutation high efficiency effect

Pending Publication Date: 2020-05-19
CHINA INST FOR RADIATION PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The issue of susceptibility to radiation damage among individuals with different genetic backgrounds was mentioned in ICRP Publication 60 and Publication 79. There is a high-risk subgroup in the population that is highly sensitive to ionizing radiation damage, and the existence of this subgroup increases. uncertainties in radiation carcinogenic risk

Method used

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  • Use of UIMC1 gene as molecular marker for judging radiation injury susceptibility
  • Use of UIMC1 gene as molecular marker for judging radiation injury susceptibility
  • Use of UIMC1 gene as molecular marker for judging radiation injury susceptibility

Examples

Experimental program
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Effect test

Embodiment 1

[0015] 1. Preliminary screening of molecular markers for susceptibility to radiation damage by using whole exome capture sequencing technology

[0016] 1) Sample collection, irradiation and chromosome aberration analysis

[0017] Collect peripheral blood from healthy adult males aged 20-30, give 0, 2Gy 60 Co gamma ray irradiation. Chromosomal aberration analysis was performed on samples irradiated with 2Gy γ-rays, and the population was divided into susceptible group, general group and non-susceptible group. Chromosomes were harvested after blood samples were cultured for 52 hours after irradiation, and slides were prepared. 200 metaphases were analyzed per sample.

[0018] 2) Genomic DNA extraction from peripheral blood

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Abstract

The invention belongs to the technical field of biological detection, and relates to a use of a UIMC1 gene as a molecular marker for judging radiation injury susceptibility. By utilizing the use of the UIMC1 gene as the molecular marker for judging the radiation injury susceptibility, detection of radiation damage can be efficiently performed at low cost according to whether an rs1700490 site of the UIMC1 gene mutates or not.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and relates to the use of UIMC1 gene as a molecular marker for judging radiation damage susceptibility. Background technique [0002] At present, there are about 200,000 radiation workers in our country. Radiation workers have to accept occupational exposure for a long time in their daily work, and the damage of cumulative exposure is obvious to susceptible people. Therefore, an effective method is needed to judge whether the personnel meet the job requirements to reduce occupational injuries. [0003] In addition, radiation therapy is one of the main treatments for malignant tumors, and more than 50% of cancer patients require radiation therapy. However, even with the same radiation therapy plan, the degree of radiation injury in different patients is different. The reason is mainly related to the individual differences in susceptibility to radiation injury: under the same treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 原雅艺董娟聪张睿凤刘红艳任越党旭红张忠新左雅慧柴栋良
Owner CHINA INST FOR RADIATION PROTECTION
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