Application of desmethylisobordine in preparation of medicament for preventing and/or treating bladder smooth muscle dysfunction

A technology of desmethylisoboldine and dysfunction, which is applied in the field of bladder smooth muscle dysfunction treatment, can solve the problems of anticholinergic drugs limiting clinical application and unsatisfactory curative effect, and achieve the goal of reducing contractility, reducing contraction, and good regulation Effect

Active Publication Date: 2021-02-26
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the treatment methods for overactive bladder mainly include behavior therapy, drug therapy, neuromodulation therapy, etc. In severe cases, detrusor muscle transection or bladder enlargement surgery can be used, but the curative effect is not satisfactory, and the side effects of anticholinergic drugs are limited to a certain extent. also limits its clinical application

Method used

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  • Application of desmethylisobordine in preparation of medicament for preventing and/or treating bladder smooth muscle dysfunction
  • Application of desmethylisobordine in preparation of medicament for preventing and/or treating bladder smooth muscle dysfunction
  • Application of desmethylisobordine in preparation of medicament for preventing and/or treating bladder smooth muscle dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]The effect of desmethylisoboldine on the contractility of detrusor muscle

[0034]Take the mouse bladder, use a scalpel to cut the bladder into 4 parts (each part is 5~10mm×1~5mm), and tie the two ends of each part into a circle with No. 6 surgical thread, and one end is attached to the fixed part. On the hook, the other end is connected to a tension sensor to measure tension (HarvardApparatus, USA). The tissue is immersed in an organ bath containing Kreb's solution. The solution is maintained at 37°C and oxygen is continuously supplied. The gas composition is as follows: 950mL / LO2+50mL / L CO2. After adapting to a tension-free state for 0.5h, stretch the bladder tissue to a tension of 0.5g and balance for 1h. The changes in tension were displayed on the physiological recorder (Harvard Apparatus, USA & LabChart, New Zealand), and the data was recorded by the software (LabChart Software).

[0035]After equilibrium, EFS (40V, 2-30Hz, 0.5ms pulse duration, 10s) caused nerve-mediated cont...

Embodiment 2

[0037]Effect of desmethylisoboldine on contractility of mouse bladder smooth muscle (DSM)

[0038]1) Take the mouse bladder, use a scalpel to cut the bladder into 4 parts (each 5-10mm×1-5mm), and tie the two ends of each part into a circle with No. 6 surgical thread, and attach one end to it. On a fixed hook, the other end is connected to a tension sensor to measure tension (HarvardApparatus, USA). The tissue is immersed in an organ bath containing Kreb's solution. The solution is maintained at 37°C and oxygen is continuously supplied. The gas composition is introduced As follows: 950mL / LO2+50mL / L CO2. After adapting to a tension-free state for 0.5h, stretch the bladder tissue to a tension of 0.5g and balance for 1h. The tension change is displayed on the graph recorder (HarvardApparatus, USA & LabChart, New Zealand), and the data is recorded by the software (LabChartSoftware). After the tension is balanced, observe the contractile ability of the mouse DSM to α,β-methylene ATP (100μmol...

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Abstract

The invention provides application of norisoboldine in preparing drugs for preventing and / or treating a bladder smooth muscle dysfunction, and belongs to the technical field of treatment of the bladder smooth muscle dysfunction. The norisoboldine has a very good and obvious regulating function on a bladder smooth muscle function, can lower the contraction ability of detrusor, obviously reduces a contraction response caused to alpha, beta-methylene adenosine 5'-triphosphate (ATP), CCh and KCl by the detrusor, can further obviously reduce contraction caused by electrical field stimulation (EFS),can be used for treating overactive bladder, and can also be used for treating various diseases including uroclepsia, hyperuresis and the like.

Description

Technical field[0001]The invention belongs to the technical field of treatment of bladder smooth muscle dysfunction, and in particular relates to the application of desmethylisoboldine in the preparation of drugs for preventing and / or treating bladder smooth muscle dysfunction.Background technique[0002]The bladder has the functions of storing urine and urinating. These two functions are realized by the relaxation and contraction of smooth muscle under the regulation of nerves and receptors. Maintaining normal dilation and contraction of the detrusor is particularly important for maintaining normal urine storage and urination. The change of bladder function is one of the important factors that cause symptoms of lower urinary tract diseases such as frequent urination, urinary urgency, and urinary incontinence. Changes in smooth muscle function are not only an important pathogenesis of overactive bladder or detrusor overactivity, but also a necessary condition for involuntary detrusor ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/473A61P13/00A61P13/02A61P13/10
CPCA61K31/473A61P13/00A61P13/02A61P13/10
Inventor 操红缨
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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