Ion exchange fiber chloroquine suspension and preparation method thereof

An ion exchange fiber and cation exchange technology, applied in the field of medicine, can solve problems such as large fluctuation of blood drug concentration, and achieve the effects of convenient swallowing, overcoming poor compliance and easy acceptance.

Active Publication Date: 2020-06-19
广州康健医学科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention has developed a lower concentration ion-exchange fiber chloroquine drug delivery system for the first time, which not only overcomes the shortcomings of solid preparations, but also solves the problem of large fluctuations in blood drug concentration of conventional tablets, and the chloroquine oral liquid preparation prepared simultaneously has good Taste, improve patient compliance, less side effects, can be used as an antiviral sustained-release oral solution for daily use, and can also be used as a drug for rheumatoid arthritis, systemic lupus erythematosus and other autoimmune diseases

Method used

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  • Ion exchange fiber chloroquine suspension and preparation method thereof
  • Ion exchange fiber chloroquine suspension and preparation method thereof
  • Ion exchange fiber chloroquine suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preparation of ion exchange fiber chloroquine suspension

[0042] The preparation method of ion exchange fiber chloroquine suspension is as follows:

[0043] (1) Take the cation exchange fiber and soak it with water, ethanol, 1.0 mol / L NaOH solution and 1.0 mol / L HCl solution successively to convert the fiber into hydrogen form, filter with suction, and rinse with deionized water until it is neutral. A 60-mesh filter is used for primary screening, and then an 80-mesh filter is used for the second sieving of the ionic fibers that have passed through the sieve, and the ionic fibers of the second sieve that have not passed are taken out and dried for use to obtain raw material 1;

[0044] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at 45°C for 20 minutes to obtain solution 1;

[0045] (3) Weigh 10g of xylitol and 0.05g of EDTA and add them to 300ml of deionized water to obtain solution 2;

[0046] (4) Mix solution ...

Embodiment 2

[0048] Example 2 Preparation of ion exchange fiber chloroquine suspension

[0049] The preparation method of ion exchange fiber chloroquine suspension is as follows:

[0050] (1) Take the cation exchange fiber and soak it with water, ethanol, 1.0 mol / L NaOH solution and 1.0 mol / L HCl solution successively to convert the fiber into hydrogen form, filter with suction, and rinse with deionized water until it is neutral. Use an 80-mesh filter for primary screening, and then use a 100-mesh filter for the second sieving of the ionic fibers that have passed through the sieve, and take the ionic fibers of the second sieve that failed to pass and dry for use to obtain raw material 1;

[0051] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at 45°C for 20 minutes to obtain solution 1;

[0052] (3) Weigh 10g of xylitol and 0.05g of EDTA and add them to 300ml of deionized water to obtain solution 2;

[0053] (4) Same as Example 1;

[0054] (5) S...

Embodiment 3

[0055] Example 3 Preparation of ion exchange fiber chloroquine suspension

[0056] The preparation method of ion exchange fiber chloroquine suspension is as follows:

[0057] (1) Take the cation exchange fiber and soak it with water, ethanol, 1.0 mol / L NaOH solution and 1.0 mol / L HCl solution successively to convert the fiber into hydrogen form, filter with suction, and rinse with deionized water until it is neutral. A 100-mesh filter is used for primary screening, and then a 120-mesh filter is used for the second sieving of the ionic fibers that have passed through the sieve, and the ionic fibers of the second sieve that have not passed are taken out and dried for use to obtain raw material 1;

[0058] (2) Weigh 50g of raw material 1, 60g of chloroquine phosphate, add 500ml of deionized water, and stir at 45°C for 20 minutes to obtain solution 1;

[0059] (3) Weigh 10 g of xylitol and 0.05 g of EDTA and add them to 300 ml of deionized water to obtain solution 2.

[0060] (4) Same as E...

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Abstract

The invention discloses an ion exchange fiber chloroquine suspension and a preparation method thereof. The ion exchange fiber chloroquine suspension comprises the following components: 20-100 g / L of chloroquine or a chloroquine derivative, 10-150 g / L of strong-acid-type cation exchange fibers, 10-30 g / L of a flavoring agent, 0.01-0.1 g / L of a complexing agent and the balance of deionized water. The invention researches and develops a sustained-release drug delivery system of the ion exchange fiber chloroquine suspension for the first time, prepares the suspension into a chloroquine oral liquid, overcomes the defects of traditional dosage forms such as chloroquine tablets and injections and the defect of unstable blood concentration of common oral liquids, and enables a drug to be easier toabsorb and more convenient to swallow. Moreover, the suspension disclosed by the invention is good in taste, high in patient compliance and small in side effect, and can be used as the drug for resisting viruses in daily life and treating rheumatic arthritis, systemic lupus erythematosus and other autoimmune diseases.

Description

Technical field [0001] The invention belongs to the field of medical technology. More specifically, it relates to an ion exchange fiber chloroquine suspension and a preparation method thereof. Background technique [0002] For a long period of time, chloroquine has been used clinically as a first-line antimalarial drug, but its application has declined due to the emergence of drug-resistant plasmodium. In addition, chloroquine has a mild immunosuppressive effect, so it is used to treat rheumatoid arthritis, systemic lupus erythematosus and other autoimmune diseases. The lysosomal nature of chloroquine allows it to specifically act on the lysosome after entering the cell, which leads to an increase in the pH within the lysosome, losing the ability to bind to the autophagosome, and exerting an inhibitory effect on autophagy. In addition, chloroquine has a broad-spectrum antiviral effect, and has a good inhibitory effect on HIV-1, influenza B virus, hepatitis A virus, and SARS-rel...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/107A61K47/32A61K31/4706A61P33/06A61P29/00A61P19/02A61P37/02A61P31/12
CPCA61K9/107A61K31/4706A61K47/32A61P19/02A61P29/00A61P31/12A61P33/06A61P37/02
Inventor胡博李相玲唐有根
Owner广州康健医学科技有限公司