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Traditional Chinese medicine composition for improving climacteric endocrine as well as preparation method and application of composition

A composition and endocrine technology, applied in the field of medicine, can solve problems such as application restrictions and use of endocrine disorders, and achieve the effects of enhancing immunity, improving endocrine disorders, and enhancing human immunity

Inactive Publication Date: 2020-07-03
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although HRT can achieve the purpose of improving symptoms, improper use can also cause further endocrine disorders in patients and increase the risk of heart disease events, stroke, breast cancer, endometrial cancer, ovarian cancer, etc. Therefore, the safety of this therapy is in the academic field There have always been differences in the world, making its application subject to certain restrictions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A traditional Chinese medicine composition for improving menopausal endocrine, made of the following medicines: 120g of fresh rose, 100g of kudzu root, 100g of black soybean, 100g of wolfberry, 60g of astragalus and 60g of Rehmannia glutinosa; the preparation method comprises the following steps:

[0027] S1: Weigh the above-mentioned medicines in proportion except fresh roses, dry and pulverize each medicine to 400 meshes, weigh fresh roses in proportions, and cut them into pieces for later use;

[0028] S2: After mixing the above-mentioned drugs, add a 30% v / v ethanol aqueous solution and conduct ultrasonic extraction at 60°C and 50W power for 30 minutes to obtain an ultrasonic extract;

[0029] S3: The ultrasonic extraction liquid is separated by AB-8 macroporous resin, followed by water, 10% v / v ethanol aqueous solution, 30% v / v ethanol aqueous solution, and 50% v / v ethanol aqueous solution. Carry out gradient elution with ethanol aqueous solution, collect the eluen...

Embodiment 2

[0031] A traditional Chinese medicine composition for improving menopausal endocrine, made of the following medicines: 240g of fresh roses, 180g of kudzu root, 180g of black beans, 180g of medlar, 120g of astragalus and 120g of Rehmannia glutinosa; the preparation method comprises the following steps:

[0032] S1: Weigh the above-mentioned medicines in proportion except fresh roses, dry and pulverize each medicine to 300 meshes, weigh fresh roses in proportions, and cut them into pieces for use;

[0033]S2: After mixing the above-mentioned drugs, add a 60% v / v ethanol aqueous solution and conduct ultrasonic extraction at 60°C and 70W power for 2 hours to obtain an ultrasonic extract;

[0034] S3: The ultrasonic extraction liquid is separated by AB-8 macroporous resin, followed by water, 10% v / v ethanol aqueous solution, 30% v / v ethanol aqueous solution, and 50% v / v ethanol aqueous solution. Carry out gradient elution with ethanol aqueous solution, collect the eluent with ethan...

Embodiment 3

[0036] A traditional Chinese medicine composition for improving menopausal endocrine, made of the following medicines: 140g of fresh rose, 120g of kudzu root, 120g of black soybean, 120g of wolfberry, 80g of astragalus and 80g of rehmannia; the preparation method comprises the following steps:

[0037] S1: Weigh the above-mentioned medicines in proportion except fresh roses, dry and pulverize each medicine to 300 meshes, weigh fresh roses in proportions, and cut them into pieces for use;

[0038] S2: After mixing the above-mentioned drugs, add a 55% v / v ethanol aqueous solution and perform ultrasonic extraction at 35°C and 65W power for 1.5 hours to obtain an ultrasonic extract;

[0039] S3: The ultrasonic extraction liquid is separated by AB-8 macroporous resin, followed by water, 10% v / v ethanol aqueous solution, 30% v / v ethanol aqueous solution, and 50% v / v ethanol aqueous solution. Carry out gradient elution with ethanol aqueous solution, collect the eluent of ethanol aque...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for improving climacteric endocrine. The traditional Chinese medicine composition is characterized by being prepared from the following medicines in parts by weight: 120-240 parts of fresh roses, 100-180 parts of radix puerariae, 100-180 parts of black beans, 100-180 parts of fructus lycii, 60-120 parts of milkvetch root, and 60-120 parts of prepared rehmannia root. The invention also specifically discloses a preparation method and pharmaceutical application of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention follows the theory of ''monarch, minister, assistant and guide'' and compatibility of traditional Chinese medicine, and the medicines are combined toachieve the multiple functions of nourishing liver and dispelling melancholy, nourishing yin and benefiting qi, and nourishing blood and promoting blood circulation, so that the liver can be nourished, the liver qi can be smoothed, kidney water can be nourished, endocrine disorders caused by female climacteric syndrome can be significantly improved, and the traditional Chinese medicine compositionhas a good clinical treatment effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for improving menopausal endocrine and its preparation method and application. Background technique [0002] Menopause is a special physiological period for women to transition from childbearing to old age, and usually occurs between the ages of 45 and 55. After women enter menopause, due to the decline of ovarian function and the decrease of estrogen level, it causes endocrine dysfunction and autonomic dysfunction, coupled with the influence of social, family, psychological and other factors, resulting in different degrees and manifestations of physical, nervous, Mental symptoms, as well as the body's metabolic disorders, known as "menopausal syndrome" (Climacteric Syndrome). [0003] Menopausal syndrome, also known as menopausal syndrome or perimenopausal syndrome, is a common and frequently-occurring disease in gynecolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P5/00A61P15/12
CPCA61K36/48A61K36/481A61K36/488A61K36/738A61K36/804A61K36/815A61K2236/333A61K2236/55A61P5/00A61P15/12A61K2300/00
Inventor 郑迎春宋梅王悦王华杰
Owner QINGDAO CENT HOSPITAL
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