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Lidocaine hydrochloride mucilage

A technology of lidocaine hydrochloride and mucilage, which is applied in the field of lidocaine hydrochloride mucilage, which can solve the problems of unfavorable elimination of gastrointestinal foam, prolonging the time of gastroscopy, and the omission of minor lesions by doctors, so as to avoid the omission of minor lesions , enhance the clarity of vision, improve the effect of bad smell and taste

Active Publication Date: 2020-07-10
浙江康德药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to achieve the effect of slowing drug absorption and delaying, too much viscous agent is added in the preparation prescription, but the viscous liquid is not conducive to eliminating the foam in the gastrointestinal tract, and more foam leads to blurred vision under the microscope. It is easy to cause doctors to miss small lesions, thereby reducing the accuracy of diagnosis and prolonging the time of gastroscopy

Method used

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  • Lidocaine hydrochloride mucilage
  • Lidocaine hydrochloride mucilage
  • Lidocaine hydrochloride mucilage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of lidocaine hydrochloride mucilage

[0032] prescription:

[0033]

[0034] Preparation Process:

[0035] (1) 200g lidocaine hydrochloride is placed in 3000ml newly made sterile water for injection, stir to dissolve completely, then add 1000g glycerin, stir;

[0036] (2) Add 40g of glacial acetic acid and newly prepared sterile water for injection to be mixed with an acetic acid solution with a concentration of 1.0% (w / v), add 15g of chitosan (viscosity 100-200mPa.s) and 5gL-menthol to be dissolved in the acetic acid solution In, then add 50g carmellose sodium, stir to make swelling completely;

[0037] (3) Mix (1) and (2) evenly, use 0.1N sodium hydroxide solution to adjust the pH=6.5, add sterile water for injection to 10000g, mix evenly, fill the obtained glue, cover it, and steam it out at 115°C Bacteria for 30 minutes (take samples before high-temperature sterilization, and leave them open at room temperature for 15 days for a l...

Embodiment 2

[0038] Embodiment 2: the preparation of lidocaine hydrochloride mucilage

[0039] prescription:

[0040]

[0041] Preparation process: the preparation concentration of the acetic acid solution is 1.5% (w / v), and other steps are the same as in Example 1.

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Abstract

The invention provides a lidocaine hydrochloride mucilage, which is prepared from the following components in percentages by mass: 1-3% of lidocaine hydrochloride, 0.3-0.6% of carboxymethylcellulose sodium, 0.1-0.3% of chitosan, 6-12% of glycerol, 0.03-0.08% of L-menthol, 0.1-0.6% of glacial acetic acid and the balance of purified water. The amount of the carboxymethylcellulose sodium is reduced,meanwhile, through introduction of the chitosan and the L-menthol, foam in a gastrointestinal tract is removed, the vision clarity of gastroscopy is strengthened, and missing of minute lesions is avoided, thereby improving the accuracy rate of diagnosis and shortening the time of the gastroscopy.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular relates to a local anesthetic preparation, in particular to a lidocaine hydrochloride mucilage for surface local anesthesia. Background technique [0002] Local anesthetics, also referred to as local anesthetics for short, are a kind of local anesthetics that are applied locally at appropriate concentrations to human skin and mucous membranes, etc., and act on nerve endings or nerve trunks to block the conduction function of nerves and make local tissues or areas innervated by corresponding nerves Temporary reversible sensory loss occurs, first disappearing is dull persistent pain (such as tenderness), followed by sharp short-term pain, touch, and sensation. Local anesthetics are mainly administered externally, in the form of solutions, gels, ointments and pastes, applied to the skin, mucous membranes and cavities, or instilled into the eyes with eye drops, so ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/167A61K47/10A61K47/36A61K47/38A61P23/02
CPCA61K9/10A61K9/0053A61K31/167A61K47/36A61K47/38A61K47/10A61P23/02
Inventor 冯荣权胡增仁
Owner 浙江康德药业集团股份有限公司
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