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A kind of animal vaccine adjuvant and preparation method thereof

A vaccine adjuvant and animal technology, applied in the field of vaccines, can solve the problems of oil adjuvant not being metabolized, granulomas, purulent inflammatory lesions in animals, etc.

Active Publication Date: 2021-01-12
SICHUAN ANIMAL SCI ACAD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these adjuvants are not suitable for all vaccines. Aluminum colloidal adjuvants are safe and effective, but they can only stimulate humoral immunity, and adjuvants containing oil components can only induce a low level of cellular immunity, and oil adjuvants cannot be induced in animals. Metabolism, high toxicity, after injection into animals, a large part of animals will form nodules, granulomas, and individual animals may even have many side effects such as suppurative inflammatory lesions

Method used

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  • A kind of animal vaccine adjuvant and preparation method thereof
  • A kind of animal vaccine adjuvant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A preferred embodiment of the present invention provides a method for preparing an animal vaccine adjuvant, the specific steps are as follows:

[0037] Weigh 5.2g of sodium fluoride and 4g of polycarbophil, dissolve them in 900mL of water for injection, then sterilize under high pressure at 115°C for 20 minutes and cool, then add polycarbophil with a concentration of 90g / L filtered through a 0.22μm filter Cell solution 100mL, mix well, that is.

Embodiment 2

[0039] A preferred embodiment of the present invention provides a method for preparing an animal vaccine adjuvant, the specific steps are as follows:

[0040] Weigh 2g of sodium fluoride and 2g of polycarbophil potassium, dissolve them in 900mL of water for injection, then autoclave at 121°C for 30 minutes and cool, then add polycarbophil with a concentration of 80g / L filtered through a 0.22μm filter Cell solution 100mL, mix well, that is.

Embodiment 3

[0042] A preferred embodiment of the present invention provides a method for preparing an animal vaccine adjuvant, the specific steps are as follows:

[0043] Weigh 8g of sodium fluoride and 7g of polycarbophil calcium, dissolve them in 900mL of water for injection, then autoclave at 115°C for 20 minutes and cool, then add polycarbophil at a concentration of 50g / L filtered through a 0.22μm filter Cell solution 100mL, mix well, that is.

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Abstract

The invention discloses an animal vaccine adjuvant and a preparation method thereof, and belongs to the technical field of vaccines. The adjuvant comprises the following components in parts by weight:3 to 10 parts of sodium fluoride, 1 to 10 parts of polycarbophil or polycarbophil salt and 1 to 10 parts of polyinosinic cells. The preparation method comprises the following steps: dissolving 3-10 gof the sodium fluoride and 1-10 g of the polycarbophil or polycarbophil salt in 900 mL of water for injection, performing high-pressure sterilization, performing cooling, adding 100 mL of a polyinosinic acid cell water solution with the concentration of 10-100 g / L, and performing uniform mixing to obtain the adjuvant. The adjuvant disclosed by the invention not only can be applied to inactivatedvaccines and subunit vaccines, but also can be applied to live vaccines, and has the characteristics of high safety, small side effects and low costs.

Description

technical field [0001] The invention belongs to the technical field of vaccines, in particular to an animal vaccine adjuvant and a preparation method thereof. Background technique [0002] Vaccine adjuvants are a type of vaccine that is not immunogenic in itself, but when used in combination with antigens, it can non-specifically enhance animal body’s recognition of antigens, and assist animals to produce cellular immune responses, humoral immune responses or / and mucous membranes against specific antigens Substances of the immune response. [0003] Under normal circumstances, both inactivated vaccines and subunit vaccines require the use of adjuvants to achieve the intended effect, so vaccine adjuvants are very important and indispensable in the process of inactivated vaccines and subunit vaccines. After nearly 100 years of development, a variety of adjuvants have been formed. The commonly used adjuvants include mineral salt adjuvant, Freund's adjuvant, white oil adjuvant, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61P37/04
CPCA61K39/39A61K2039/52A61K2039/55505A61K2039/55511A61P37/04
Inventor 周远成邝声耀阴文奇
Owner SICHUAN ANIMAL SCI ACAD
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