A kind of animal vaccine adjuvant and preparation method thereof

A vaccine adjuvant and animal technology, applied in the field of vaccines, can solve the problems of oil adjuvant not being metabolized, granulomas, purulent inflammatory lesions in animals, etc.
CN111420046BActive Publication Date: 2021-01-12SICHUAN ANIMAL SCI ACAD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN ANIMAL SCI ACAD
Publication Date
2021-01-12

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Abstract

The invention discloses an animal vaccine adjuvant and a preparation method thereof, and belongs to the technical field of vaccines. The adjuvant comprises the following components in parts by weight:3 to 10 parts of sodium fluoride, 1 to 10 parts of polycarbophil or polycarbophil salt and 1 to 10 parts of polyinosinic cells. The preparation method comprises the following steps: dissolving 3-10 gof the sodium fluoride and 1-10 g of the polycarbophil or polycarbophil salt in 900 mL of water for injection, performing high-pressure sterilization, performing cooling, adding 100 mL of a polyinosinic acid cell water solution with the concentration of 10-100 g / L, and performing uniform mixing to obtain the adjuvant. The adjuvant disclosed by the invention not only can be applied to inactivatedvaccines and subunit vaccines, but also can be applied to live vaccines, and has the characteristics of high safety, small side effects and low costs.
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Description

technical field

[0001] The invention belongs to the technical field of vaccines, in particular to an animal vaccine adjuvant and a preparation method thereof. Background technique

[0002] Vaccine adjuvants are a type of vaccine that is not immunogenic in itself, but when used in combination with antigens, it can non-specifically enhance animal body’s recognition of antigens, and assist animals to produce cellular immune responses, humoral immune responses or / and mucous membranes against specific antigens Substances of the immune response.

[0003] Under normal circumstances, both inactivated vaccines and subunit vaccines require the use of adjuvants to achieve the intended effect, so vaccine adjuvants are very important and indispensable in the process of inactivated vaccines and subunit vaccines. After nearly 100 years of development, a variety of adjuvants have been formed. The commonly used adjuvants include mineral salt adjuvant, Freund's adjuvant, white oil adjuvant, ...

Claims

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