Schiff base-based polyurethane/chitosan self-healing hydrogel and preparation method thereof

A technology of polyurethane and chitosan, applied in medical science, bandages, etc., can solve problems such as poor mechanical properties, achieve good mechanical properties, superior antibacterial properties, and convenient use

Active Publication Date: 2020-08-11
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, chitosan hydrogels based on Schiff bases often use small molecule dialdehydes or polyaldehydes as cross-linking agents. Representative, but mostly used in injectable hydrogels due to poor mechanical properties

Method used

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  • Schiff base-based polyurethane/chitosan self-healing hydrogel and preparation method thereof
  • Schiff base-based polyurethane/chitosan self-healing hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A kind of polyurethane / chitosan self-healing hydrogel based on Schiff's base, which is prepared by cross-linking imine bonds with aldylated polyurethane and chitosan as raw materials; amino groups and aldehydes in the chitosan The molar ratio of aldehyde groups in the alkylated polyurethane is 1:1; the solid content of the self-healing hydrogel is 10.5%.

[0031] The above-mentioned preparation method of polyurethane / chitosan self-healing hydrogel based on Schiff base specifically comprises the following steps:

[0032] (1) Weigh 40g of polyethylene glycol and 5.34g of isophorone diisocyanate and dissolve them in 20g of acetone at 60°C. After fully dissolving, add 0.009g of organotin catalyst dropwise and keep at 60°C for 30 minutes to obtain a colorless Transparent polyurethane prepolymer solution.

[0033] (2) Take 1.1g 2,4-dihydroxybenzaldehyde and disperse it in 20g acetone, add the dispersion liquid to the polyurethane prepolymer solution prepared in step (1), aft...

Embodiment 2

[0039]A kind of polyurethane / chitosan self-healing hydrogel based on Schiff's base, which is prepared by cross-linking imine bonds with aldylated polyurethane and chitosan as raw materials; amino groups and aldehydes in the chitosan The molar ratio of aldehyde groups in the alkylated polyurethane is 3:1; the solid content of the self-healing hydrogel is 8.7%.

[0040] The above-mentioned preparation method of polyurethane / chitosan self-healing hydrogel based on Schiff base specifically comprises the following steps:

[0041] (1) Weigh 40g of polyethylene glycol and 5.56g of isophorone diisocyanate and dissolve them in 20g of acetone at 60°C. After fully dissolving, add 0.009g of organotin catalyst dropwise and keep at 60°C for 25 minutes to obtain a colorless Transparent polyurethane prepolymer solution.

[0042] (2) Take 1.38g 2,4-dihydroxybenzaldehyde and disperse it in 10g acetone, add the dispersion liquid to the polyurethane prepolymer solution prepared in step (1), afte...

Embodiment 3

[0048] A kind of polyurethane / chitosan self-healing hydrogel based on Schiff's base, which is prepared by cross-linking imine bonds with aldylated polyurethane and chitosan as raw materials; amino groups and aldehydes in the chitosan The molar ratio of aldehyde groups in the alkylated polyurethane is 1:1; the solid content of the self-healing hydrogel is 10.6%.

[0049] The above-mentioned preparation method of polyurethane / chitosan self-healing hydrogel based on Schiff base specifically comprises the following steps:

[0050] (1) Weigh 40g of polyethylene glycol and 5.56g of isophorone diisocyanate and dissolve them in 20g of acetone at 60°C. After fully dissolving, add 0.009g of organotin catalyst dropwise and keep at 60°C for 25 minutes to obtain a colorless Transparent polyurethane prepolymer solution.

[0051] (2) Weigh 1.38g 2,4-dihydroxybenzaldehyde and disperse it in 10g of acetone, add the dispersion to the polyurethane prepolymer solution prepared in step (1), and r...

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Abstract

The invention discloses polyurethane/chitosan self-healing hydrogel based on Schiff base, which is prepared by crosslinking aldehyde polyurethane and chitosan serving as raw materials through an iminebond. Wherein the molar ratio of an aldehyde group in the aldehyde polyurethane to an amino group in the chitosan is 1: (1-3); wherein the solid content of the self-healing hydrogel is 8%-12%. The polyurethane/chitosan self-healing hydrogel based on the Schiff base has good mechanical property, excellent antibacterial property, good self-healing property, swelling property and pH responsiveness,is convenient to use, and can prolong the service life of the hydrogel.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and also belongs to the technical field of biomedical materials, and specifically relates to a Schiff base-based polyurethane / chitosan self-healing hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of polymer with three-dimensional microstructure, which not only can swell in water without losing its structural integrity, but also has excellent softness, biocompatibility and permeability, and is currently the most promising biomaterial in the field of biomedicine. One of the promising materials. However, hydrogels are susceptible to comprehensive damage from external factors during processing and use, and microcracks will occur inside, resulting in shortened service life. Therefore, introducing the self-healing function into hydrogel materials is beneficial to prolong the service life of materials and improve their safety. The properties of self...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L75/08C08L5/08A61L26/00C08G18/75C08G18/66C08G18/48C08G18/10C08G18/32
CPCA61L26/0066A61L26/008C08G18/10C08G18/4833C08G18/6674C08G18/755C08J3/075C08J3/246C08J2305/08C08J2375/08C08J2405/08C08J2475/08C08G18/3215
Inventor 吉晓莉易曌吴力立
Owner WUHAN UNIV OF TECH
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