Application of specific iga in the preparation of kits for evaluating covid-19 disease risk, disease severity and prognosis assessment

A COVID-19, severity technology, applied in the biomedical field, can solve problems such as false negatives and increase serological evidence, and achieve the effect of improving the cure rate, enhancing individual early warning and prevention and control

Active Publication Date: 2021-11-02
SHENZHEN HAIBO BIOTECHNOLOGY CO LTD
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AI Technical Summary

Problems solved by technology

The sampling process, nucleic acid extraction process and qPCR detection process of the nucleic acid detection process are prone to false negatives
[0004] In addition, the current serological detection method for COVID-19 is only mentioned in the seventh edition of the trial version of the new coronavirus pneumonia diagnosis and treatment plan issued by the National Health and Medical Commission, that is, "serum positive for new coronavirus-specific IgM antibodies and IgG antibodies ; Serum new coronavirus-specific IgG antibody changes from negative to positive or the recovery period is 4 times or more higher than the acute period" is the serological basis for confirmed cases

Method used

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  • Application of specific iga in the preparation of kits for evaluating covid-19 disease risk, disease severity and prognosis assessment

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Experimental program
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Embodiment

[0108] In this application, 37 COVID-19 patients (experimental group) and 61 non-COVID-19 patients (control group) were tested and compared. The study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University.

[0109] The serum samples of the above-mentioned experimental group and control group were inactivated at 56°C for 30 min, and the serum samples of the experimental group and the control group were detected with a chemiluminescence immunoassay kit and a KAESER 6600 automatic chemiluminescence immunoassay analyzer (Chongqing Cosman Biotechnology Co., Ltd.). Spike protein (S protein)-specific IgA, IgM, and IgG antibody levels against SARS-CoV-2 in serum samples. Among them, the chemiluminescent immunoassay kit adopts two-step indirect immunoassay, serum samples are incubated with magnetic beads, unbound materials are washed by magnetic separation, magnetic beads are collected and incubated with acridinium ester markers; substrate...

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Abstract

This application provides the application of specific IgA as a detection target in evaluating the risk, severity, and prognosis of COVID-19; by evaluating the risk of COVID-19, enhancing individual early warning and prevention and control is beneficial to the The spread of COVID-19 is controlled; by evaluating the severity of individual COVID-19, medication can be administered to patients of different degrees; at the same time, the prognosis of patients can be evaluated, and timely monitoring can be carried out to improve the cure of patients Rate.

Description

technical field [0001] This application relates to the field of biomedicine, in particular to the application of specific IgA in evaluating the risk, severity and prognosis of COVID-19. Background technique [0002] The rapid spread of novel coronavirus pneumonia (Corona Virus Disease 2019, COVID-19) around the world has had a major impact on people's health. The World Health Organization has declared the disease a global pandemic, but there is no clinical gold standard for testing for the infection. [0003] At present, the problem of false negatives of nucleic acid detection methods that are widely used is serious. The false negative rate of viral nucleic acid detection in suspected cases is relatively high. For patients with confirmed COVID-19, the positive rate is only 30% to 50%. The sampling link, nucleic acid extraction link and qPCR detection link of the nucleic acid detection process are prone to false negative problems. [0004] In addition, the current serologic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6854G01N2800/26G01N2800/50G01N2800/52G01N2800/56
Inventor 刘志刚刘杰肖小军方章福刘晓宇
Owner SHENZHEN HAIBO BIOTECHNOLOGY CO LTD
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