Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of plant-based soft capsule rubber, preparation method and application thereof

A technology of soft capsules and rubber skins, which is used in capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc., to achieve the effects of excellent anti-aging ability, improved wettability, and reduced crystallinity

Active Publication Date: 2021-06-22
JIANGSU FOOD & PHARMA SCI COLLEGE
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still relatively little research on the rubber of plant-based soft capsules. Although there have been some patent reports, the formula still needs to be improved and perfected

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of plant-based soft capsule rubber, preparation method and application thereof
  • A kind of plant-based soft capsule rubber, preparation method and application thereof
  • A kind of plant-based soft capsule rubber, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: A plant-based softgel rubber:

[0076] The present embodiment provides a kind of plant-based soft capsule rubber, and its specific components and contents thereof include:

[0077]

[0078]

[0079] The degree of substitution of the hydroxypropyl starch is 0.4, and

[0080] The grafting ratio of lactic acid to hydroxypropyl starch is 21%.

[0081] The soft capsule rubber described in this embodiment is specifically prepared through a method comprising the following steps:

[0082] 1) Preparation of hydroxypropyl starch / lactic acid graft copolymer:

[0083] 1.1) Add 10g of hydroxypropyl cornstarch to 75g of 0.25mol / L sodium carbonate solution, heat up to 68°C at 4°C / min for gelatinization for 45min, then add 40g of lactic acid, reduce the system pressure to 0.1MPa, then raise the temperature to 80°C, and react 1h;

[0084]1.2) Step 1.1) Add acetone after the system is lowered to room temperature, settle, filter with suction and dry at 50°C to obtain ...

Embodiment 2

[0096] Example 2: Another Plant-Based Softgel Gum:

[0097] This embodiment provides another plant-based soft capsule rubber. The components, formulations, and preparation methods of the soft capsule rubber are basically the same as those in Example 1. The only difference is that in the components of this embodiment, fiber Instead of cellulose / polylactic acid graft copolymer, cellulose is used to prepare soft capsule rubber without polylactic acid graft modification.

Embodiment 3

[0098] Example 3: Another Plant-Based Softgel Gum:

[0099] This embodiment provides another plant-based soft capsule rubber, the composition, formula and preparation method of the soft capsule rubber are basically the same as those in Example 1, the only difference is that no fiber is added to the components of this embodiment Vegetable / polylactic acid graft copolymer.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
degree of substitutionaaaaaaaaaa
degree of graftingaaaaaaaaaa
Login to View More

Abstract

The present invention relates to the technical field of soft capsule rubber materials, in particular to a plant-based soft capsule rubber, a preparation method and its application. The plant-based soft capsule rubber comprises: hydroxypropyl starch / lactic acid graft copolymer, fiber Vegetable / polylactic acid graft copolymer, plasticizer, gelling agent, edible coloring and water; Wherein, the degree of substitution of the hydroxypropyl starch is not higher than 0.58, and the grafting rate of lactic acid to hydroxypropyl starch Between 14 and 25%. The main material of the soft capsule rubber comes from plants, which has an extremely excellent disintegration time limit, which is conducive to the rapid release of the capsule in the body, and has excellent friability, disintegration time, tensile strength and elongation at break. At the same time, its anti-aging ability is excellent, and the storage life can be significantly extended.

Description

technical field [0001] The invention relates to the technical field of soft capsule rubber materials, in particular to a plant-based soft capsule rubber, a preparation method and an application thereof. Background technique [0002] Soft capsule refers to the liquid or molten drug mixture containing certain active ingredients, or the solution, suspension, emulsion or semi-solid (paste, etc.) mixture containing solid drug dispersion, sealed in a spherical or oval shape. Capsules with soft capsules. The advantage of soft capsules is that the embedded content is completely isolated from external factors such as air, so as to prevent the active ingredients in the content from being destroyed by external factors; therefore, 1) oily drugs, low melting point drugs; 2) light-sensitive , Drugs that are unstable or easily oxidized when exposed to heat and humidity; 3) Drugs with bad odor and trace active drugs; 4) Drugs with volatile components that are easy to escape; 5) Hydrophobic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/34
CPCA61K9/4808A61K9/4816A61K47/34A61K47/36
Inventor 李艳霞傅淋然其他发明人请求不公开姓名
Owner JIANGSU FOOD & PHARMA SCI COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com