Application of daphnetin in preparation of medicine for preventing and/or treating muscular atrophy, sarcopenia and exercise capacity decline caused by age increase

A technique for muscle atrophy and exercise ability, applied in the fields of biology and medicine, to achieve the effect of significantly improving the decline of motor function, improving swimming ability, and enhancing the grasping power of limbs

Inactive Publication Date: 2020-11-06
XI AN JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no application in the prevention and treatment of muscle atrophy, sarcopenia, and decline in exercise capacity caused by aging or aging

Method used

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  • Application of daphnetin in preparation of medicine for preventing and/or treating muscular atrophy, sarcopenia and exercise capacity decline caused by age increase
  • Application of daphnetin in preparation of medicine for preventing and/or treating muscular atrophy, sarcopenia and exercise capacity decline caused by age increase
  • Application of daphnetin in preparation of medicine for preventing and/or treating muscular atrophy, sarcopenia and exercise capacity decline caused by age increase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Daphnetin can enhance the grasping ability of SAMP8 premature aging mice

[0033] Progeria model mice SAMP8 were given daphnetin for 3 months, and then had free access to feed and water for 4 months. At the age of 10 months, the grip test was carried out, and the results were as follows: figure 1 shown. from figure 1 It can be seen that, compared with the control group SAMP8+ddH 2 Compared with O, daphnetin can improve the grip strength of SAMP8 mice, and the above behavioral results show that daphnetin can improve the limb strength of SAMP8 mice.

Embodiment 2

[0034] Example 2 Daphnetin can enhance the exercise capacity of SAMP8 premature aging mice

[0035] 3 days after the end of the grip test, a 60s swimming test was carried out, and the results were as follows: figure 2 shown, from figure 2 It can be seen that the swimming distance of the mice in the SAMP8+Daphnetin group in 60s was compared with that of the SAMP8+ddH 2 O mice were significantly longer. The above experimental results proved that the SAMP8 mice administered with daphnetin were compared with the control group SAMP8+ddH 2 O mice have better exercise ability, further confirming that daphnetin has the effect of improving aging-related exercise ability deterioration.

Embodiment 3

[0036] Example 3 daphnetin can enhance the gastrocnemius muscle weight of SAMP8 progeria mice

[0037] One week after the swimming test, the mice were sacrificed, and the leg muscles of the mice were isolated and weighed. The results were as follows: image 3 shown. from image 3 It can be seen that the SAMP8 mice administered with daphnetin were compared with those administered with ddH 2 The mass of gastrocnemius muscle in SAMP8 mice of O was significantly increased, suggesting that daphnetin can improve sarcopenia.

[0038] In conclusion, daphnetin can improve aging-related motor function degeneration and prevent aging-related muscle atrophy and sarcopenia.

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Abstract

The invention discloses an application of daphnetin in preparation of a medicine for preventing and/or treating muscular atrophy, sarcopenia and exercise capacity decline caused by age increase. The application is discovered for the first time, and the daphnetin is proved to be capable of obviously enhancing the grabbing force of four limbs of an aged mouse, improving the swimming exercise capacity of the aged mouse and improving the muscle quality in an aged mouse model.

Description

technical field [0001] The invention belongs to the fields of biology and medicine, and relates to the application of daphnetin in the preparation of health food or medicine for preventing and / or treating muscle atrophy, sarcopenia and motor decline caused by aging or aging. Background technique [0002] The human body movement system mainly includes bones, skeletal muscles, and joints. Among them, muscles are the driving force for the body to achieve movement. The amount of muscle mass is significantly related to the size of strength. However, as we age, the human body will be accompanied by muscle atrophy and loss of muscle mass. This phenomenon is also considered to be a sign of the aging process in the human body. Senile muscle loss or atrophy will aggravate health risks such as falls, injuries, and disabilities in the elderly. Therefore, maintaining muscle mass and maintaining muscle strength in the aging process is of great significance for delaying the aging proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P39/06A61P21/00A23L33/105
CPCA23V2002/00A61K31/37A23L33/105A61P21/00A61P39/06A23V2200/316A23V2250/21A23V2200/302
Inventor 龙建纲高佩佩樊思越王文昊罗宁峰张天培张爽曦彭韵桦刘健康
Owner XI AN JIAOTONG UNIV
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